National Journals

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Author: search.filters.author.Shalini GEnd date: 2019

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    EVALUATING MULTI-TARGET EFFICIENCY OF PHYTOCOMPOUNDS AGAINST DIABETES MELLITUS - AN IN SILICO APPROACH
    (BIOINFO Drug Targets, 2014-05-29) Jeyam M; Priyadharshini K; Ravikumar P; Shalini G
    Diabetes mellitus (DM) is a complex mulitifactorial metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. In the present study, the phytocompounds were selected from traditionally used medicinal plants and nutraceuticals and the selected targets for Diabetes Mellitus were Peroxisome Proliferator Activate Receptor gamma, Fructose 1-6 bisphosphate and Dipeptidyl peptidase IV. Using Glide (Schrodinger module), in silico docking of the phytocompounds with these targets was carried out and their efficacy was evaluated against DM. The docking results of the phytocompouds were compared with the corresponding synthetic drugs in order to explore the multi -targeting efficiency of the phytocompounds for treating diabetes. Of the 27 selected compounds from 12 plants, Glucobrassicin present in Capparis spinosa and Brassica oleracea (Broccoli) and Epigallocatechin gallate (EGCG) present in Camellia sinensis showed better interactions and glide score with all the 3 receptors than the corresponding drugs / inhibitor. From the present study it is concluded that the phytocompounds can be used as an appropriate lead molecules against diabetes. Further the nutraceuticals, Aegle marmelos, Brassica oleracea, Glycine max, Zingiber officinale, Capparis spinosa and Trigonella foenum graecum can be added as food supplement to reduce the risk of diabetes
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    PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF WHEAT GRAINS AND SEEDLINGS
    (Journal of Pharmaceutical and Scientific Innovation, 2014) Ravikumar P; Shalini G; Jeyam M
    The phytochemical profiles and antioxidant activity of methanolic extract of Wheat Grains (WG) and 3 days old wheat seedlings (3dWS) were evaluated in the present study. Phytochemical analysis was performed for alkaloids, flavonoids, phenols, saponins, steroids, terpenoids, proteins and carbohydrates in WG and 3dWS extracts. Antioxidant activity was evaluated using DPPH and ABTS radical scavenging activity, total phenolic content and reducing power ability. In this study, the results of WG were compared with 3dWS. The results of phytochemical analysis showed the presence of all the above phytochemicals in the both 3dWS and WG extracts. When compared with WG, the 3dWS possesses high nutritional contents and antioxidant activity. Hence, it is suggested to add wheat seedling in the daily diet to reduce many diseases caused by antioxidant deficiency.