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Author: search.filters.author.Rathinam, Raja

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    EFFICACY OF EISENIA BICYCLIS PHLOROTANNINS IN THE TREATMENT OF DIABETES AND REDUCING INFLAMMATION
    (Elsevier, 2023-04) Rathinam, Raja; Shanmugam, Hemaiswarya; Kulanthaiyesu, Arunkumar; N, Mathiyazhagan; Sabariswaran, Kandasamy; A, Arun; P, Ramasamy
    Crude phlorotannins from Eisenia bicyclis (CPEb), a common perennial brown seaweed were screened for pharmacological activities such as anti-inflammatory, antioxidant, and antidiabetic effects. Crude Phlorotannins (CPEb) studied by FT-IR, LC-MS, UHPLC, and UV chromatography showed the occurrence of dieckol, 8, 8'-bieckol, fucofuroeckol, and the carotenoid, zeaxanthin (0.5 mg/kg). LPS, an inflammatory mediator, enhanced the production of cytokines such IL-1 (interleukin-1), IL-6 (interleukin-6), IL-8 (interleukin-8), IL-10 (interleukin-10), TNF-α (tumour necrosis factor-α), chemokine CXCL10, and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) in differentiated THP1 macrophage cells. On differentiated human monocytic cell line LPS-induced THP1 cells, CPEb was found to have anti-inflammatory effects by reducing the expression of IL-1, IL-6, IL-8 (1.2 fold), CXCL10, NF-κB, and TNF-α. CPEb promoted 2-NBDG absorption in differentiated C2C12 myotubes under both basal (16.08%) and insulin-stimulated (51.09%) conditions. CPEb increased IRS/AKT-dependent glucose absorption and also activates the AMPK pathway. Anti-α-glucosidase, anti-inflammatory and antioxidant activity of CPEb indicate their role in treating hyperglycemia by scavenging ROS and inflammatory responses.
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    THE CURRENT STATE OF ALGAE IN WASTEWATER TREATMENT AND ENERGY CONVERSION: A CRITICAL REVIEW
    (Elsevier, 2023-06) Sabariswaran, Kandasamy; Mathiyazhagan, Narayanan; Rathinam, Raja; Kesavan, Devarayan; R, Kavitha
    Due to the rapid expansion of the global economy and population, there aren't enough water resources accessible for direct human consumption. Therefore, water remediation will unavoidably take center stage on a worldwide platform. The development of microalgae can be supported by several types of wastewater (WW). They might be able to clean up pollutants from industry and urban effluents. Due to its low energy requirements, microalgae's capacity to survive in various environmental circumstances, and the potential to convert WW nutrients into high-value chemicals, microalgae-based wastewater treatment (WWT) has already received attention. Recent studies have reported using microalgae to remove pharmaceutical compounds and pesticides from wastewater produced by industrial and agricultural processes and removing nutrients from wastewater from WWTs. As a result, utilizing microalgae for both wastewater treatment and biofuel production could be a cost-effective solution to these challenges. This review emphasizes recent developments in the production of microalgae for WW cleanup. Additionally, it highlights the current problems and opportunities in the emerging algae-based sector.