2.Book Chapter (13)

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Author: search.filters.author.Devi, Balasundaram Saraswathy Chithra

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    INTEGRATED MOLECULAR STRATEGIES FOR ENHANCED PRODUCTION OF ANTI-CANCER COMPOUNDS FROM ABUTILON HIRTUM (LAM.) SWEET (MALVACEAE) (Book Chapter)
    (CRC Press, 2025-01-01) Devi, Balasundaram Saraswathy Chithra; Tharani S; Elakkiya M.R; Krishnasreya M; Wesley, P. Servin
    Abutilon hirtum (Lam.) Sweet, a member of the Malvaceae family, has garnered attention for its rich reservoir of bioactive compounds, particularly those with potential anti-cancer properties. Various studies have explored the medicinal potential of Malvaceae plants, revealing a diverse array of bioactive compounds like alkaloids, cardiac glycosides, saponins, tannins, phenolic acids, and mucilages. Studies indicate that extracts or compounds derived from Abutilon hirtum exhibit promising effects against various cancer types. Several species within the Abutilon genus have also been recognized for their medicinal properties, with Abutilon hirtum being particularly rich in beneficial phytochemicals. To enhance the production of these secondary metabolites, a range of biotechnological methods are employed. Plant cell suspension culture and in vitro adventitious root culture are vital techniques used to boost secondary metabolite production. These methods have been successful in various plant species, generating compounds with pharmacological, nutraceutical, and industrial significance. Elicitation techniques, including the use of abiotic and biotic elicitors, are utilized to stimulate secondary metabolite production in suspension and adventitious root cultures, thereby increasing biomass and the concentration of pharmacologically active compounds during plant growth. Additionally, the use of nanomaterials as elicitors presents a promising avenue for augmenting secondary metabolite production and bolstering plant resilience to environmental stressors, with potential benefits for human health. Moreover, the review discusses recent advancements in biotechnological approaches, such as metabolic engineering and genetic modification, to further amplify the production of bioactive molecules from Abutilon hirtum. Overall, this synthesis provides insights into the potential of biotechnological interventions for optimizing the production of anti-cancer compounds from Abutilon hirtum, paving the way for future research and applications in cancer therapeutics.
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    INTEGRATED MOLECULAR STRATEGIES FOR ENHANCED PRODUCTION OF MEDICINAL PLANT-DERIVED ALKALOIDS (Book Chapter)
    (CRC Press, 2025-01-01) Devi, Balasundaram Saraswathy Chithra; Krishnasreya M; Tharani S.; Elakkiya M.R
    Medicinal plants continue to be an important source of life-saving drugs for humankind. The secondary metabolites responsible for plant defense mechanisms through cytotoxic activity toward microbial pathogens have proved to be useful as antimicrobial medicines in humans. One such group of secondary metabolites is alkaloids; they are nitrogenous organic heterocyclic molecules that have pharmacological effects on humans and other animals. They are used as antihypertensives, sedatives, antitumor agents, anticholinergic drugs, anesthetics, psychoactive, analgesics, antispasmodics, and antibacterials, and are also used in treating neurodegenerative disorders and mood disorders. In plants, alkaloids are present only in small quantities. This chapter reviews the molecular strategies that can be employed to increase alkaloid production from medicinal plants.
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    MUTAGENESIS FOR ENHANCED SECONDARY METABOLITES PRODUCTION IN MEDICINAL PLANTS (Book Chapter)
    (CRC Press, 2025-01-01) Tharani S; Mutharaian V.N; Thirugnanasampandan R; Moin, Sarmad; Devi, Balasundaram Saraswathy Chithra
    Medicinal plants have long been recognized as valuable sources of secondary metabolites with diverse pharmacological and therapeutic properties. The controlled manipulation of plant genomes through mutagenesis offers a promising avenue to enhance the production of these bioactive compounds. This abstract discusses the principles and applications of mutagenesis techniques, including chemical and radiation-based methods, as tools to induce genetic variations in medicinal plants. It also explores the subsequent identification and selection of high-yielding mutants, along with their stable propagation and evaluation under controlled and field conditions. Induced mutations have been successfully employed to develop enhanced versions of several therapeutic plants. This approach has the potential to substantially increase the yield of secondary metabolites, thereby addressing the growing need for these compounds. Additionally, it contributes to the sustainable cultivation of medicinal plants, reducing pressure on wild populations. However, it is vital to consider ethical, environmental, and regulatory aspects when employing these techniques to achieve the desired enhancement of secondary metabolites. The application of mutagenesis in enhancing secondary metabolite production offers a pathway to harness the full potential of medicinal plants for their therapeutic and economic value.