F-KCW-Department Publications
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Item A HAND BOOK FOR RESEARCH PROJECT PROPOSALS(PSGR Krishnammal College for Women, 2009) Krishnasamy, R; Rama, Narayanan; Sasikala, GItem ANTIBACTERIAL EFFECT OF BULBOPHYLLUM NEILGHERRENSE WT. (ORCHIDACEAE). AN INVITRO STUDY(Ancient Science of Life, 2005-12) Priya K; Krishnaveni CThe antibacterial activity of Bulbophyllum neilgherrense was tested against five species of bacteria, viz., Escherichia coli, Staphylococcus aureus, Bacillus pumilus, Pseudomonas aeruginosa and Pseudomonas putida Aqueous, ethanolic and chloroform soluble extracts of leaf and pseudobulb (5.50 w/v) were screened for their antibacterial potential. The zone of inhibition was seen to be largest when alcoholic extract was used.Item INVESTIGATIONS ON MARINE ACTINOMYCETES FROM BAY OF BENGAL NEAR GANGAVARAM COAST OF ANDHRA PRADESH.(Association of Pharmaceutical Innovators, 2009) Kumari K S; Umadevi K; Apparao AllamBay of Bengal Ocean near Gangavaram coast of Andhra Pradesh, India was investigated as a source of actinomycetes to screen for the production of novel bioactive compounds. During our investigation on marine actinomycetes from 6 different marine samples, a total of 51 actinomycetes with distinct characteristics were isolated by plating on starch casein agar medium. The antimicrobial and enzymatic activities were studied for all the isolates. The preliminary study for antimicrobial activity by cross streak method indicated that 21 isolates (41.1%) have excellent antagonistic properties. All these 21 isolates were subjected to detailed submerged fermentation studies. It was observed that 12 isolates (23.5%) exhibited antibacterial activity, 9 isolates (17.6%) showed antifungal activity while 3 isolates (5.8%) showed both antibacterial and antifungal activities. All the isolates were also subjected for the determination of enzymatic activities. 41 isolates (80.3%) exhibited amylolytic activity while 48 isolates (94.1%) showed proteolytic activity.Item TWO DISTINCT FLUORESCENT QUANTUM CLUSTERS OF GOLD STARTING FROM METALLIC NANOPARTICLES BY PH-DEPENDENT LIGAND ETCHING(Springer Link, 2008) Madathumpady, Abubaker Habeeb Muhammed; Subramani, Ramesh; Sudarson, Sekhar Sinha; Samir Kumar, Pal; Thalappil, PradeepTwo fluorescent quantum clusters of gold, namely Au25 and Au8, have been synthesized from mercaptosuccinic acid-protected gold nanoparticles of 4–5 nm core diameter by etching with excess glutathione. While etching at pH ∼3 yielded Au25, that at pH 7–8 yielded Au8. This is the first report of the synthesis of two quantum clusters starting from a single precursor. This simple method makes it possible to synthesize well-defined clusters in gram quantities. Since these clusters are highly fluorescent and are highly biocompatible due to their low metallic content, they can be used for diagnostic applications.Item SORPTION CHARACTERISTICS OF AGRO WASTE PRODUCT IN THE REMOVAL OF LEAD (II)(Elsevier, 2008-03) Muthulakshmi Andal N; Shyamaladevi NA study was conducted to investigate the sorption capacity of saw, an agro waste product for the removal of lead(II)(Pb)(II) from aqueous systems. Commercially available saw dust were purchased from small-scale domestic units, such as furniture mart and varying concentrations of Pb(II) were used for Pb(II)-SD system. The study involved adding 75 mg of particles size of saw dust into iodine flasks, which contained 50 ml of the 10 mg/liter adsorbate. Pb solutions were filtered and analyzed for the residual concentration, using Atomic Absorption Spectrophotometer. The absorption investigations were carried out, by varying the particle size, contact time, initial concentration, dosage, pH of the medium, influence of cations, anions, co-ions, and the effect of temperature. It was observed that the sorption rate for the Pb(II) saw dust system were dependent on the availability of active surface sites on the adsorbentItem STRUCTURAL AND DYNAMICAL STUDIES OF ALL-TRANS AND ALL-CIS CYCLO[(1R,3S)-Γ-ACC-GLY]3 PEPTIDES(Springer Link, 2008-09-16) Gopalan, Praveena; Ponmalai, KolandaivelThe quantum chemical and molecular dynamics studies have been performed to infer the structural changes of all-trans and all-cis forms of cyclo[(1R,3S)-3-aminocyclohexanecarboxylicacid(γ-Acc)-α-Glycine(Gly)]3 hexapeptide. The backbone conformations of the above peptide have been analyzed using the valence and peptide deformation angles applying B3LYP/6–311G** level of theory. The conformational preference of the backbone of all-trans and all-cis cyclo[(1R,3S)-γ-Acc-Gly]3 hexapeptides is found to depend on the puckering of cyclohexane rings. The non-uniform distribution of water inside the cavity is observed, where sometimes water molecules formed a chain like conformation through hydrogen bond networks while traversing the pore of all-cis cyclo[(1R,3S)-γ-Acc-Gly]3 peptide. Larger relaxation times of the order of a hundred to two hundred pico seconds for active site…water hydrogen bond interactions were noticed. The hydrophobic nature of the cavity of all-trans cyclo[(1R,3S)-γ-Acc-Gly]3 due to the presence of cyclohexane moiety has been analyzed. Further this investigation emphasized on the non-transport of molecules through the pore of all-trans cyclo[(1R,3S)-γ-Acc-Gly]3 peptide due to the obstruction produced by cyclohexane groups.Item DIETARY INFLUENCES ON CANCER IN AND AROUND COIMBATORE, INDIA: A GIS BASED RISK ASSESSMENT STUDY(2008-01) P B, Harathi; Prashanthi, Devi; Sumithashini, Valarmathi; Somanathan, BalasubramanianDiet habits play a key role in the health of person with the time, type and method of intake of food. Several studies has been carried out to study the influence of diet on the risk of cancer among various populations. Geographic Information Systems (GIS) technologies are evolving rapidly and increasingly used for mapping disease occurrence as a way to explore spatial and temporal patterns. Specifically, the use of area-level socioeconomic factors, person habits and multilevel geographic approaches has been recommended to help evaluate single or multiple influences on cancer incidence and other cancers and health conditions using statistical and spatial analysis. The present study attempts in mapping the dietary influences on the risk of cancer among 3000 patients screed for cancer at Coimbatore, India. Information such as the age of the person, sex, marital status, tobacco use history, year of cancer diagnosis, and stage and grade of tumor were extracted from the incidence data. Spatial maps were prepared using GIS to identify the influence of diet on the risk of cancer. The result shows significant variations in diet habits and the cancer risk among different stages of diagnosis. These geographic spatial patterns inform and may facilitate the design of intervention programs to target areas of exposure.Item TRACING THE SPATIO TEMPORAL PATH OF PEAK MALARIA INCIDENCES USING WALK ANALYSIS AND GIS(2008) S, Valarmathi; M, Prashanthi Devi; P B, Harathi; S, BalasubramanianEpidemic risk is a dynamic phenomenon with changing geographic pattern based on the temporal variations, in determinant factors including weather and other eco epidemiological characteristics of area at high risk. Epidemic early warning systems should take account of non uniform effects of these factors by space and time and hence temporal dimensions could be considered in spatial models of epidemic risks (Abeku, 2004).Based on this concept, the present study is aimed to analyse the geographical based time expansion of malarial transmission. Monthly malaria incidences data for a period of 101 months (Jan 1996- May 2004) recorded from Salem distrct, India were used for the study To estimate the spatial effects based on two components i.e., the overall difference among the regions and the rate of change over time for these regions, a spatio-temporal analysis for fixed and random effects are performed. The model was used to identify if additional cases are coming from malarial predominant areas (High Incidence areas), from moderate areas, or from low incidence areas. The conditional auto regressive model is used to model the random effects. Correlated Walk and Random Walk analysis is used to show the movement of the disease over time. Markov Chain Monte Carlo simulation is used to obtain estimates of the posterior and predictive quantities of interest. CrimeStat is used to analyze statistically and Arcview 3.2 is used to map the results at different time periods and maps of smoothed time incidence. The results have significant implication over space and time and can be used for malaria control activities in the study area and also other infected areas. Based on the time and space aspect, the regional malarial control authorities have an opportunity to assess the risk of encountering the disease infection and to plan prevention measures accordingly. This study also provides an indication to any association between time trend and basic malarial incidence.Item SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME 2-AMINO-4-(1, 1′-BIPHENYL-4-YL)-6-ARYL-6H-1, 3-THIAZINES(Journal of Sulfur Chemistry, 2007-02-01) N, Ingarsal; P, Amutha; S, NagarajanA series of new 2-amino-4-(1,1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines has been synthesized, characterized by IR, 1H NMR, 13C NMR, mass and elemental analyses and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that the compounds had better activity against tested organisms than the reference norfloxacin.Item HISTORY OF GROWTH AND REFORMS OF BRITISH MILITARY ADMINISTRATION IN INDIA, 1848-1949(Language In India, 2008-09-09) HemalathaMilitary Administration means proper organization of the army into an efficient one so that it becomes a powerful force and defends the nation at all times of crisis. Therefore the survival of a country depends on its defence. A military or military force is a collective of men, machines and equipment that form an army. While it can refer to an armed force, it generally refers to a permanent, professional force of soldiers or guerrillas - trained exclusively for the purpose of warfare. The doctrine that asserts the primary of a military with in a society is called militarism. Ever since the dawn of history people have fought many wars. Families against families, tribes against tribes, groups against groups. But this kind of skirmishes are not wars. They were called fights. War is a political institution and necessary evil.