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Author: search.filters.author.Jone Kirubavathy, S

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    CO(II) COMPLEX OF 2-AMINO-6-METHYLBENZOTHIAZOLE: SYNTHESIS, STRUCTURE AND BIOLOGICAL EVALUATION
    (Indian Journal of Chemistry, 2016-11) Jone Kirubavathy, S; Velmurugan, R; Karvembu, R; Bhuvanesh, N S P; Enoch, I V M V; Mosae Selvakumar, P; Chitra, S
    Cobalt(II) complex of 2-amino-6-methylbenzothiazole has been synthesized and characterized by various physicochemical methods. The ligand 2-amino-6-methylbenzothiazole acts as monodentate, neutral ligand with N as the donor site. The molecular structure of the title complex has been determined by single crystal X-ray diffraction studies. The Co(II) complex shows significant antioxidant activity against DPPH radical. The complex shows cytotoxicity with a IC50 value of 14.12 µM against MCF-7 cell line. In addition, the complex shows good antimicrobial and anti-tuberculosis activities against various microbes and mycobacterium tuberculosis respectively. DNA binding of the title complex has been investigated by absorption spectroscopic technique, which reveals that the complex acts as minor groove binder. These results have been validated by molecular docking studies
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    SYNTHESIS, CHARACTERIZATION, SINGLE-CRYSTAL XRD, AND BIOLOGICAL EVALUATION OF NICKEL(II) SALEN SULFADIAZINE COMPLEX
    (Taylor & Francis Online, 2016) Jone Kirubavathy, S; Velmurugan, R; Tamilarasan, B; Karvembu, R; Bhuvanesh, N S P; Chitra, S
    Nickel(II) salen sulfadiazine complex was prepared and characterised by the spectral studies such as FT-IR, UV-Vis and NMR, and single-crystal XRD. The nickel(II) complex was screened for in vitro antimicrobial activities against various test organisms Aeromonas hydrophila, Serratia marcescens, Bacillus licheniform, Pseudomonas aeruginosa, Acinetobacter baumanii, Aspergillus niger, and Candida albicans by the well diffusion method and in vitro anticancer activity against the human breast cancer cell line HeLa. The NiO obtained by the thermal decomposition of Ni (salen) sulfadiazine complex was characterised using TEM images and their SAED pattern