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Author: search.filters.author.Pugazhendhi, Arivalagan

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    THEORETICAL INSIGHTS AND ANTICANCER POTENTIAL OF 2,6-BIS((E)-(2-AMINO-4-NITROPHENYLIMINO)METHYL)-4-METHOXYPHENOL AND ITS BINUCLEAR CU(II) COMPLEX (Article)
    (John Wiley and Sons Ltd, 2025-02) Praveen S; Parinamachivayam G; Jeyaraman P; Prabakarakrishnan R; Natarajan A; Geetha K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Pugazhendhi, Arivalagan; Kandasamy, Sabariswaran
    This study explores the synthesis and applications of a new Schiff base, 2,6-bis((E)-(2-amino-4-nitrophenylimino)methyl)-4-methoxyphenol (HL), and its copper(II) complexes. The Schiff base was prepared by reacting 2-amino-4-nitroaniline with 2,6-diformyl-4-methoxyphenol and characterized using techniques like microanalysis, UV–Vis, IR spectroscopy, 1H-NMR, and LC–MS, confirming its structure. Theoretical studies provided insights into its molecular geometry and electronic properties. Cyclic voltammetry of the copper complex revealed diffusion-controlled electrochemical behavior, involving a single-electron transfer. Both the Schiff base and its Cu(II) complexes exhibited promising anticorrosion and anticancer activities, highlighting their multifunctional potential in industrial and biomedical applications. This study emphasizes the importance of comprehensive characterization in developing innovative materials with practical uses.
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    DECIPHERING THE IMPORTANCE OF NANOENCAPSULATION TO IMPROVE THE AVAILABILITY OF BIOACTIVE MOLECULES IN FOOD SOURCES TO THE HUMAN BODY (Article)
    (Elsevier Ltd, 2025-02) Pugazhendhi, Arivalagan; Alshehri, Mohammed Ali Mohammed Ali; Kandasamy, Sabariswaran; Sarangi, Prakash Kumar; Sharma, Ashutosh
    Various bodily functions are maintained, and health benefits are provided by food-derived bioactive components. Fruits and vegetables contain numerous beneficial components, including vitamins, minerals, antioxidants, enzymes, and phytonutrients. However, the body's ability to absorb these substances at a given rate and degree frequently limits their bioavailability. If food-derived bio actives are used as therapeutic or dietary interventions, this limitation can result in low efficacy and suboptimal results. Recently, nanotechnology has been a useful method for increasing the bioavailability of bioactive compounds produced from food. Active ingredients can be delivered and absorbed more efficiently with the help of nanotechnology. By altering their size or surface properties, bioactive components can be made more soluble, permeable, and bioavailable through nanotechnology. The present review will provide an overview of the various bioactive components, the application of nanotechnology to improve the availability of bioactive molecules to humans and animals, and the challenges and safety concerns associated with nanotechnology in the production of food-derived bioactive molecules.