International Journal
Permanent URI for this collectionhttps://dspace.psgrkcw.com/handle/123456789/2986
Browse
7 results
Search Results
Item THE PHARMACEUTICAL POTENTIAL OF CRUDE ETHANOL LEAF EXTRACT OF PEDALIUM MUREX (L.)(Elsevier, 2022) Mathiyazhagan, Narayanan; Arunachalam, Kiran; Devarajan, Natarajan; Sabariswaran, Kandasamy; Sabarathinam, Shanmugam; Maha, Alshiekheid; Hesham S, Almoallim; Arivalagan, PugazhendhiThe purpose of this study was to determine the antibacterial competence of various solvent leaf extracts of Pedalium murex against bacteria that cause skin infections such as Staphylococcus aureus, (folliculitis), Streptococcus pyogenes (impetigo), and Corynebacterium sp. (pitted keratolysis). The presence of phytochemicals, antioxidant activity, and cytotoxicity on the Human Embryonic Kidney (HEK 293) cell line were also studied. The ethanol extract contained more phytochemical ingredients (saponins, flavonoids, alkaloids, terpenoids, phenolics, quinones, and betacyanin) than the other extracts. An increased concentration of ethanol extract demonstrated excellent antibacterial activity (zone of inhibition) against bacteria such as S. aureus, S. pyogenes, and Corynebacterium sp. and it followed by methanol extract. This is the first report on the antibacterial activity of an ethanol extract of P. murex against bacteria that cause skin infections. The average minimum inhibitory concentration (MIC) value of ethanol extract was found as 13.64 mg mL−1. In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl free radical scavenging assay, the crude ethanol (87.25 and 83.24 % respectively) and methanol extracts (81.41% and 78.39% respectively) showed excellent antioxidant activity. The cytotoxicity study (4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) revealed that the crude ethanol extract of P. murex effectively supported the proliferation of HEK 293 cell line with the absence of considerable number of cell death even at 500 mg mL−1. The findings concluded that the components present in the ethanol extract could be used in drug formulations to combat bacteria that cause skin infections without causing side effects.Item ASSESSING POLLUTANT SORPTION EFFICIENCY OF MODIFIED AND UNMODIFIED BIOCHAR WITH BACILLUS CEREUS ON CONTAMINATED LAKE WATER: IMPLICATIONS FOR ORYZA SATIVA SEEDLING AND ARTEMIA FRANCISCANA LARVAE VIABILITY(Springer Link, 2023-10-02) Mathiyazhagan, Narayanan; Ramesh, Subramani; Sabariswaran, KandasamyThis study evaluated the efficacy of biochar in removing pollutants from a polluted lake. Biochar, both with and without Bacillus cereus, was assessed for its sorption potential. The treated water samples were analyzed for toxicity using Oryza sativa and Artemia franciscana larvae. The lake water exceeded permissible limits for pH, turbidity, dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD), and various metals. The 10-day biosorption study with different treatment groups (MB, UMB, MBB, UMBB, and BC) revealed that the MBB group exhibited remarkable pollutant sorption potential. It achieved pollutant removal percentages of 33.35% for Cd, 15.73% for As, 26.21% for Cr, 32.72% for Pb, 32.81% for Zn, 23.58% for Cu, 5.44% for Cl, 22.01% for Ni, 28.2% for Hg, and 4.19% for SO42−. MBB-treated lake water showed no toxicity, confirming pollutant removal by metal-tolerant Bacillus cereus in modified biochar.Item MICROALGAE AS A MULTIPOTENTIAL ROLE IN COMMERCIAL APPLICATIONS: CURRENT SCENARIO AND FUTURE PERSPECTIVES(Elsevier, 2022-01-15) Sabariswaran, Kandasamy; Bo, Zhang; Zhixia, He; Narayanamoorthy, Bhuvanendran; Ahmed I., EL-Seesy; Qian, Wang; Mathiyazhagan, Narayanan; Palaniswamy, Thangavel; Mudasir A., DarMicroalgal feedstocks have gained tremendous potential for sustainable biofuel production in recent years. For biofuel processing, thermochemical, biochemical, and transesterification processes are used. Many researchers have recently become interested in the hydrothermal liquefaction of microalgae. Renewable biofuel production from microalgae, as well as a broad range of value-added co-products, describe its potential as a biorefinery feedstock from this perspective. Microalgae convert solar energy into carbon storage compounds, such as TAG (triacylglycerols), which can then be converted into biodiesel, bioethanol, and bio-methanol. Microalgae are considered to be the most attractive source of biofuel production for all the organisms used. This review explored the percentage of oil content, chemical composition, and lipid content of microalgae. This analysis depicts the various aspects of microalgal species for biofuel conversion. Also, other bioenergy and value-added items are discussed briefly.Item CURRENT STATUS OF MICROBES INVOLVED IN THE DEGRADATION OF PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) POLLUTANTS IN THE AQUATIC ECOSYSTEM(Elsevier, 2022-05-01) Mathiyazhagan, Narayanan; Mostafa, El-sheekh; Ying, Ma; Arivalagan, Pugazhendhi; Devarajan, Natarajan; Gajendiran, Kandasamy; Rathinam, Raja; Saravana Kumar, R.M; Suresh, Kumarasamy; Govindasamy, Sathiyan; Geetha, R; Balaji, Paulraj; Guanglong, Liu; Sabariswaran, KandasamyContamination of aquatic systems with pharmaceuticals, personal care products, steroid hormones, and agrochemicals has been an immense problem for the earth's ecosystem and health impacts. The environmental issues of well-known persistence pollutants, their metabolites, and other micro-pollutants in diverse aquatic systems around the world were collated and exposed in this review assessment. Waste Water Treatment Plant (WWTP) influents and effluents, as well as industrial, hospital, and residential effluents, include detectable concentrations of known and undiscovered persistence pollutants and metabolites. These components have been found in surface water, groundwater, drinking water, and natural water reservoirs receiving treated and untreated effluents. Several studies have found that these persistence pollutants, and also similar recalcitrant pollutants, are hazardous to a variety of non-targeted creatures in the environment. In human and animals, they can also have severe and persistent harmful consequences. Because these pollutants are harmful to aquatic organisms, microbial degradation of these persistence pollutants had the least efficiency. Fortunately, only a few wild and Genetically Modified (GMOs) microbial species have the ability to degrade these PPCPs contaminants. Hence, researchers have been studying the degradation competence of microbial communities in persistence pollutants of Pharmaceutical and Personal Care Products (PPCPs) and respective metabolites for decades, as well as possible degradation processes in various aquatic systems. As a result, this review provides comprehensive information about environmental issues and the degradation of PPCPs and their metabolites, as well as other micro-pollutants, in aquatic systems.Item MARINE BIORESOURCES ARE A BOON FOR BIOPLASTIC PRODUCTION AS AN ALTERNATIVE TO CONVENTIONAL PLASTICS—A REVIEW(SpringerLink, 2023-08-30) Mathiyazhagan, Narayanan; Jintae, Lee; Selvaraj, Barathi; Sabariswaran, KandasamyThe constant rise in global demand for plastic products has led to an uninterrupted increase in the production and utilization of petroleum-based conventional plastics. This has resulted in significant contamination of plastic waste due to its non-biodegradable nature, particularly within aquatic ecosystems, while the availability of petroleum resources is decreasing. Additionally, although bioplastics have been introduced as alternatives to traditional plastics, their primary production from plant sources has raised concerns regarding their harmful effects on ecosystems and human well-being. In response to these challenges, marine-based bioplastics have emerged as a promising and economically feasible solution to meet the growing demand for plastic products. Marine bioresource–based bioplastics possess favorable physicochemical properties and exhibit ease of degradation, making them attractive compounds for various applications. However, implementing marine bioplastics on a large scale requires further investigation. Therefore, the main objectives of this review are to emphasize the existing scientific gaps within the specific research area and clearly state the review’s objective view. Hence, this review provides a comprehensive summary of micro and microorganisms derived from marine resources for bioplastic production and explores potential applications in promoting human welfare without causing harm to the ecosystem.Item PHYTOCHEMICAL PROFILE AND LARVICIDAL ACTIVITY OF AQUEOUS EXTRACT OF OCIMUM AMERICANUM AGAINST MOSQUITO VECTORS(SpringerLink, 2023) Mathiyazhagan, Narayanan; Vijay A; Sabariswaran, Kandasamy; Omaima, Nasif; Sulaiman Ali, Alharbi; Ramalingam, Srinivasan; Kavitha RThe primary goal of this research was to evaluate the phytochemicals, including bioactive components of Ocimum americanum extracts and assess their larvicidal potential against 3rd and 4th instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus. The aqueous extraction process on O. americanum provides higher yield (9.61 ± 0.11%) and a significant volume of phytochemicals (tannins, saponins, terpenoids, flavonoids, alkaloids, protein, and carbohydrate) than other solvents (methanol, ethanol, acetone, petroleum ether, and chloroform) extracts. Fourier-transform infrared spectroscopy and high-performance liquid chromatography analyses revealed about eight predominant phytochemicals/functional groups in O. americanum aqueous extract. Surprisingly, in gas chromatography–mass spectrometry analysis, about 30 bioactive components were found in the aqueous extract of O. americanum, the majority of which had previously been identified as medicinally valuable bioactive components. Furthermore, these bioactive components containing aqueous extract demonstrated significant larvicidal activity against 3rd and 4th instar larvae of A. aegypti, An. stephensi, and C. quinquefasciatus after 24 h of treatment at concentrations ranging from 35 to 50 mg mL−1. Thus, their outstanding larvicidal potential on 3rd and 4th instar larvae, the phytochemicals present in the aqueous extract of O. americanum could be used to control mosquito duplication and vector-borne diseases.Item ANTIOXIDANT AND ANTICANCER POTENTIAL OF ETHYL ACETATE EXTRACT OF BARK AND FLOWER OF TECOMA STANS (LINN) AND IN SILICO STUDIES ON PHYTOLIGANDS AGAINST BCL 2 AND VEGFR2 FACTORS(Elsevier, 2023-02-15) Mathiyazhagan, Narayanan; Anburaj, Gothandapani; Rajasudha, Venugopalan; Manikandan, Rethinam; Sakunthala, Pitchai; Tahani, Awad Alahmadi; Hesham S, Almoallim; Sabariswaran, Kandasamy; Kathirvel, BrindhadeviThis study was designed to appraise the antioxidant and anticancer competence of solvent extracts of Tecoma stans (Linn) and analyze the phytoligands interaction against Bcl 2 VEGFR2 through in silico studies. The phytochemical analysis revealed that the ethyl acetate extract contains more number of pharmaceutically valuable phytochemicals than other solvent extracts. Among the various phytochemicals, flavonoid was found as a predominant component, and UV–Vis- spectrophotometer analysis initially confirmed it. Hence, the column chromatogram was performed to purify the flavonoid, and High-performance liquid chromatography (HPLC) was performed. It revealed that the flavonoid enriched fraction by compared with standard flavonoid molecules. About 84.69% and 80.43% of antioxidant activity were found from ethyl acetate extract of bark and flower at the dosage of 80 μg mL−1 with the IC50 value of 47.24 and 43.40 μg mL−1, respectively. In a dose-dependent mode, the ethyl acetate extract of bark and flower showed cytotoxicity against breast cancer cell line MCF 7 (Michigan Cancer Foundation-7) as up to 81.38% and 80.94% of cytotoxicity respectively. Furthermore, the IC50 was found as 208.507 μg mL−1 and 207.38 μg mL−1 for bark and flower extract correspondingly. About 10 medicinal valued flavonoid components were identified from bark (6) and flower (4) ethyl acetate extract through LC-MS analysis. Out of 10 components, the 3,5-O-dicaffeoylquinic acid (ΔG -8.8) and Isorhamnetin-3-O-rutinoside (ΔG -8.3) had the competence to interact with Bcl 2 (B-Cell Lymphoma 2) and VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) respectively with more energy. Hence, these results confirm that the ethyl acetate extract of bark and flower of T. stans has significant medicinal potential and could be used as antioxidant and anticancer agent after some animal performance study.