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Item IN SILICO APPROACH TOWARDS ANTIINFLAMMATION AND ANTICANCER STUDIES ON PHYTOCONSTITUENTS DERIVED FROM CISSUS QUADRANGULARIS(Chemical Publishing Co, 2019) Edathil, Vidya; Selvi, GopalEthanobotanical and traditional uses of plant Cissus quadrangularis has initiated the phytochemical investigation of the plant. The stem of the plant was subjected for successive solvent extraction with petroleum ether, ethyl acetate, chloroform and ethanol. The crude extract were column choromatographed. Among 20 constituents isolated ascorbic acid, quercetin, phytol and luteol were identified. Later those phytochemicals were subjected for molecular docking in Autodock 4.2 to examine their pharmacological activity. The results obtained showed that these compounds can be further carry over for in vivo analysis.Item SYNTHESIS AND X-RAY STUDY OF DISPIRO 8-NITROQUINOLONE ANALOGUES AND THEIR CYTOTOXIC PROPERTIES AGAINST HUMAN CERVICAL CANCER HELA CELLS(Royal Society of Chemistry, 2019) Shyamsivappan, Selvaraj; Vivek, Raju; Saravanan, Arjunan; Arasakumar, Thangaraj; Subashini, Gopalan; Suresh, Thangaraj; Shankar, Ramasamy; Mohan, Palathurai SubramaniamA series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and benzylamine with (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for in vitro cytotoxic activity against the human cervical cancer cell line HeLa. The compounds have exhibited potent inhibition against human cervical cancer cells and insignificant toxicity to normal cells. The compounds 6d, 6a, 6h, 6b, and 6e induced apoptosis of HeLa cells, through ROS influx. The expression levels of proteins involved in the mitochondrion-related pathways were detected, and Western blot analysis showed that apoptosis occurred via activation of caspase-3.Item A MN3O4 NANOSPHERES@RGO ARCHITECTURE WITH CAPACITIVE EFFECTS ON HIGH POTASSIUM STORAGE CAPABILITY(Royal Society of Chemistry, 2019) Nithya, Chandrasekaran; Vishnuprakash, Palanivelu; Gopukumar, SukumaranA two dimensional (2D) Mn3O4@rGO architecture has been investigated as an anode material for potassium-ion secondary batteries. Herein, we report the synthesis of a Mn3O4@rGO nanocomposite and its potassium storage properties. The strong synergistic interaction between high surface area reduced graphene oxide (rGO) sheets and Mn3O4 nanospheres not only enhances the potassium storage capacity but also improves the reaction kinetics by offering an increased electrode/electrolyte contact area and consequently reduces the ion/electron transport resistance. Spherical Mn3O4 nanospheres with a size of 30–60 nm anchored on the surface of rGO sheets deliver a high potassium storage capacity of 802 mA h g−1 at a current density of 0.1 A g−1 along with superior rate capability even at 10 A g−1 (delivers 95 mA h g−1) and cycling stability. A reversible potassium storage capacity of 635 mA h g−1 is retained (90%) after 500 cycles even at a high current density of 0.5 A g−1. Moreover, the spherical Mn3O4@rGO architecture not only offers facile potassium ion diffusion into the bulk but also contributes surface K+ ion storage. The obtained results demonstrate that the 2D spherical Mn3O4@rGO nanocomposite is a promising anode architecture for high performance KIBs.Item FACILE DEVELOPMENT AND STRUCTURAL INVESTIGATIONS OF HAP AND HAP/TA NANOSTRUCTURES: PHOTOCATALYTIC ACTIVITY AGAINST TURQ BLUE GL DYE(Institute of Physics Publishing, 2019) Manoj, Murugesan; Mangalaraj, Devanesan; Meena, Palaniappan; Yuan, AihuaThe rising awareness of the need for a healthy environment for living systems has led to an increasing demand for suitable catalyst materials for wastewater treatment. In this connection, in the present work, the catalyst materials Hydroxyapatite and Hydroxyapatite/Tantalum (HAp/Ta) core–shell nanostructured particles were prepared through a facile nanoprecipitation method without a surfactant, chelating agents and/or ligands. The prepared nanostructured particles were characterised with the help of several analytical techniques namely XRD, FESEM, TEM, EDS, FTIR, Raman, XPS and BET. The calculated average crystallite size of HAp was found to be 26 nm and the core–shell nanorod morphology was corroborated through FESEM and TEM technique. The average length and width were found to be 44 and 16 nm respectively. The specific surface area (SSA), microporous nature and pore volume were investigated through the N2 adsorption isotherm method. The photocatalytic activity of the prepared HAp and HAp/Ta core–shell nanostructured particles was investigated on frequently used dyeing industrial dyes Turq blue GL under UV irradiation. The recorded results evince that the HAp/Ta core–shell nanorods have more catalytic activity than pure HAp and can be used as a nanophotocatalyst for industrial waste water treatment process to curb water pollution and to protect the environment.Item STRUCTURAL, MORPHOLOGICAL, OPTICAL AND DIODE PROPERTIES OF CHEMICAL BATH DEPOSITED NANO-STRUCTURED CDS THIN FILMS USING EDTA AS A COMPLEXING AGENT(Sciendo, 2019-09) Vidhya, S.N; Karunakaran, R.TCdS thin films with (1 1 1) orientation were prepared by chemical bath deposition technique at 80±5 °C using the reaction between NH4OH, CdCl2 and CS(NH2)2. The influence of annealing temperature varying from 150 °C to 250 °C was studied. X-ray diffraction studies revealed that the films are polycrystalline in nature with cubic structure. Various parameters, such as dislocation density, stress and strain, were also evaluated. SEM analysis indicated uniformly distributed nano-structured spherically shaped grains and net like morphology. Optical transmittance study showed the wide transmittance band and absence of absorption in the entire visible region. I-V characterization of p-Si/n-CdS diode and photoluminescence studies were also carried out for the CdS films.Item WEB DATA CLASSIFICATION USING SUPPORT VECTOR MACHINE BACK PROPAGATION NEURAL NETWORK(Blue Eyes Intelligence Engineering and Sciences Publication, 2019-09) Arunpriya, CThese days, the development of World Wide Web has surpassed a lot with extra desires. Extraordinary arrangement of content reports, transmission records and pictures were reachable inside the web it’s as yet expanding in its structures. Information handling is that the style of removing information’s realistic inside the web. Web mining could be a piece of information preparing that identifies with differed examination networks like data recovery, bearing frameworks and artificial insight. The data’s in these structures are very much organized from the beginning. This web mining receives a great deal of the date mining procedures to discover most likely supportive data from web substance. The ideas of web mining with its classifications were examined. The paper chiefly focused on the web Content mining undertakings along the edge of its procedures and calculations. In this paper we proposed AI calculation based order .SVM_BPM calculation grouped the web content information and thought about existing calculations our proposed arrangement calculation is high effective and less time calculation.Item SYNTHESIS, CHARACTERIZATION, SINGLE CRYSTAL XRD, IN VITRO ANTIMICROBIAL AND CYTOTOXICITY STUDY OF TRIS(ETHYLENEDIAMINE)COBALT(III)CHLORIDE OXALATE TRIHYDRATE(Elsevier B.V, 2019-11) Jone Kirubavathy, S; Velmurugan, R; Parameswari, K; Chitra, SThe complex tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate [Co(en)3]Cl(C2O4)·3H2O crystallizes in the monoclinic space group C2/c with the following unit cell parameters a = 19.9318 (13), b = 9.3344 (4), c = 19.0881 (13) Å β = 96.846(3)°, Z = 8. The crystal structure was solved by direct methods and refined by full matrix least squares procedures to a final R value of 0.0314 for 4330 observed reflections. The reported cobalt complex is six co-ordinated through amine nitrogen with distorted octahedral geometry. There are uncoordinated chloride and oxalate ions along with the water molecules. In-vitro antimicrobial activity was studied against various test organisms and found to be good. From in-vitro cytotoxic activity of the synthesized complex, the IC50 value was found to be 55.85 μg/ml.Item INHIBITION OF MILD STEEL CORROSION IN THE PRESENCE OF P-NITROPHENYL-2- IMIDAZOLINE(NACE - International Corrosion Conference Series, 2013-03-17) Nalini, D; Rajalakshmi, Rp-nitrophenyl-2-imidazoline (PNP2I) was synthesized in the laboratory and characterized by Fourier Transform Infrared Spectroscopy (FTIR) spectra and evaluated as a corrosion inhibitor for mild steel in 1M Hydrochloric acid and 0.5M Sulphuric acid by weight loss method and electrochemical studies. Results obtained revealed that PNP2I was a very good inhibitor and behaved better in 0.5M H2SO4 than in 1M HCl. Potentiodynamic polarization curves showed that PNP2I is a mixed type inhibitor. The ability of the studied inhibitor to inhibit the corrosion of mild steel was due to the presence of two hetero nitrogen atoms on the imidazoline ring and the phenyl ring attached to the imidazoline ring. The adsorption of PNP2I on the mild steel surface in both acidic media followed the Langmuir adsorption isotherm. Surface analyses were also carried out, to establish the mechanism of the corrosion inhibition of mild steel in acidic solutions. Good inhibition efficiency was evidenced in both acid solutions, furnishing an inhibition efficiency of 80 %.Item PERFORMANCE EVALUATION OF SEMANTIC BASED AND ONTOLOGY BASED TEXT DOCUMENT CLUSTERING TECHNIQUES (Conference Paper)(Elsevier, 2012) Punitha, S.C; Punithavalli, MThe amount of digital information is created and used is steadily growing along with the development of sophisticated hardware and software. This has increased the need for powerful algorithms that can interpret and extract interesting knowledge from these data. Data mining is a technique that has been successfully exploited for this purpose. Text mining, a category of data mining, considers only digital documents or text. Text Clustering is the process of grouping text or documents such that the document in the same cluster are similar and are dissimilar from the one in other clusters. This paper studies the working of two sophisticated algorithms. The first work is a hybrid method that combines pattern recognition process with semantic driven methods for clustering documents, while the second uses an ontology-based approach to cluster documents. Through experiments, the performance of both the selected algorithms is analyzed in terms of clustering efficiency and speed of clustering.Item EFFICIENT PREDICTION OF PHISHING WEBSITES USING SUPERVISED LEARNING ALGORITHMS (Conference Paper)(Elsevier B.V, 2012-12-09) Lakshmi V, Santhana; Vijaya, M SPhishing is one of the luring techniques used by phishing artist in the intention of exploiting the personal details of unsuspected users. Phishing website is a mock website that looks similar in appearance but different in destination. The unsuspected users post their data thinking that these websites come from trusted financial institutions. Several antiphishing techniques emerge continuously but phishers come with new technique by breaking all the antiphishing mechanisms. Hence there is a need for efficient mechanism for the prediction of phishing website. This paper employs Machine-learning technique for modelling the prediction task and supervised learning algorithms namely Multi layer perceptron, Decision tree induction and Naïve bayes classification are used for exploring the results. It has been observed that the decision tree classifier predicts the phishing website more accurately when comparing to other learning algorithms.