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Author: search.filters.author.Venkatesan, Hemapriya

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    SYNTHESIS AND CRYSTAL GROWTH OF CADMIUM NAPHTHOATE CRYSTAL FOR SECOND ORDER NON-LINEAR OPTICS AND CYTOTOXIC ACTIVITY
    (Taylor & Francis Online, 2022) Natarajan, Arunadevi; Ponnusamy, Kanchana; Venkatesan, Hemapriya; Shanmuga Sundari, Sankaran; Mehala, Mayilsamy
    A new organometallic crystal diaquo-di(2-hydroxy-1-naphthoate)-cadmium(II) was synthesized by slow evaporation method and characterized for optical, spectral, thermal and biological applications. Single crystal X-ray diffraction revealed that the crystal structure was monoclinic with C2 space group. The crystal perfection and atomic packing of the grown crystal were also analyzed. The presence of functional groups and different vibrational modes were studied from IR spectra. Various decomposition stages and thermal stability of the grown crystal was studied from TG-DTA data. Molar conductance and dielectric of the complex were determined. Energy Band gap, refractive index, skin depth and extinction coefficient of the crystal were calculated from UV-Visible absorption studies and by using Kurtz powder method, the second harmonic generation (SHG) efficiency was examined. In addition, the crystal was investigated for its anticancer activity on lung cancer and breast cancer cells. Using AutoDock Vina software, the binding pattern of the crystal was investigated toward target proteins Leu 862, Glu 793, Trp 796, Gln 858, Tyr 857 and Lys 861.
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    A TWO-STEP STRATEGY TO SYNTHESIS NEW AMINOGUANIDINIUM COMPLEXES: CYTOTOXIC EFFECT AND PERSPECTIVES
    (Taylor & Francis Online, 2022-05-30) Natarajan, Arunadevi; Ponnusamy, Kanchana; Venkatesan, Hemapriya; Mayilsamy, Mehala; Manoharan, Swathikaa
    The progress of transition metal complexes having anticancer activity has greater influence in cancer therapy. With the anticipation of investigating the anticancer activity and property of the transition metal complexes, Ni(II), Zn(II), and Cd(II) metal complexes of 1-hydroxy-2-naphthoic acid (1H2NA)/2-hydroxy-1-naphthoic acid (2H1NA) with aminoguanidine of ratio 1:1:2 were synthesized and characterized by spectroscopic studies like IR, UV–Vis, Thermal analysis, powder XRD, molar conductivity measurements, antimicrobial, and anticancer studies. Simple salts of 1-hydroxy-2-naphthoic acid (1H2NA)/2-hydroxy-1-naphthoic acid (2H1NA) with aminoguanidine were also prepared in different ratios viz, 1:1 and 1:2. It is characterized by spectroscopic measurements IR, UV, TG-DTA, powder XRD, molar conductivity measurements, and cytotoxic effects were also studied. Nanometal oxides of zinc complexes were prepared and surface morphological studies were investigated. The functional groups were confirmed from IR spectroscopy data. Band gap energies of all the synthesized compounds were calculated from UV–Visible spectroscopy. Various decomposition steps and the thermal stability of the compounds were determined from thermal analysis. From the molar conductivity measurements, it is confirmed that the compounds are electrolytes. SEM and TEM images confirm the rod and hexagonal shape of the respective nanometal oxides. The complexes and nanometal oxides show significant activity against antimicrobials like Staphylococcus aureus, Escherichia coli, and Aspergillus fumigates. The results of present research show that, the synthesized ligands and metal complexes at lower concentration predominantly shows higher cytotoxic activity against cancer cellular lines like MCF-7 and A-549 (human breast cancer cells and human lung cancer cells, respectively). DFT computational studies were carried out using GAUSSIAN 09 W software to understand the bonding mode and chemical parameters of the complexes were calculated using frontier molecular orbital studies.
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    NEW TRANSITION METAL(II) COMPLEXES WITH NAPHTHOATE AND AMINOGUANIDINE-BASED LIGANDS: A COMBINED SPECTROSCOPIC AND THEORETICAL STUDY WITH ITS APPLICATIONS
    (Taylor & Francis Online, 2022-10-07) Ponnusamy, Kanchana; Natarajan, Arunadevi; Balakrishnan, Prabha Devi; Sankaran, Shanmuga Sundari; Venkatesan, Hemapriya; Ill-Min, Chung
    A new series of transition metal complexes of Mn(ΙΙ), Fe(ΙΙ), Co(ΙΙ) and Ni(ΙΙ) is synthesized from aminoguanidine and 3-hydroxy-2-naphthoic acid ligands with the formula (N4H7C)2[M{(C10H6(O)(COO)}2]·2H2O. The synthesized complexes were characterized by analytical, spectral and thermal studies. The elemental analysis confirms the composition of the complexes. The XRD studies show that all the complexes are isostructural in nature. The complexes were screened for antimicrobial activity against a Gram-positive, Bacillus subtilis (B. subtilis), and a Gram-negative, Escherichia coli (E. coli), bacterial species. The antibacterial results were concurrent with the output of the DFT investigation of metal complex, showing that the aminoguanidine moiety plays a key role in biological activity. Molecular docking studies have been carried out to identify the binding affinity and the mode of interaction of metal complexes with E. coli protein (2FUM). Further the synthesized complex is used as a single source precursor for preparation of nano metal oxides. The photocatalytic activity was carried out using the metal oxide as catalyst for degradation of dye materials. The metal oxide is found to be an efficient catalyst for degradation of methyl orange dye.
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    PHYTOFABRICATION OF SILVER NANOPARTICLES FROM LIMONIA ACIDISSIMA LEAF EXTRACT AND THEIR ANTIMICROBIAL, ANTIOXIDANT AND ITS ANTICANCER PROPHECY
    (Elsevier, 2022-10) Ponnusamy, Kanchana; Venkatesan, Hemapriya; Natarajan, Arunadevi; Sankaran, Shanmuga Sundari; Ill-Min, Chung; Mayakrishnan, Prabakaran
    Green synthesis of nanoparticles by eco-friendly methods is a recent technique which draws the attention of researchers because of the reward over many conventional chemical methods. The present work focuses on aqueous Limonia acidissima leaf extract in synthesizing silver nanoparticles and its applications in a simple way. The silver nanoparticles formed were characterized by Infrared, Ultra violet-visible, X-ray diffraction, transmission electron microscopic, and atomic force microscopic techniques. The powder X-ray diffraction studies and transmission electron microscopic images reveal that the silver nanoparticles synthesized were approximately 10–40 nm and have a spherical structure. The nanoparticles were assayed for their antibacterial, antifungal and antioxidant activity. The antimicrobial studies for the silver nanoparticles show a maximum zone of inhibition of 8.8 mm for Bacillus subtilis bacteria and 8.5 mm for Candida albicans fungi at 3 and 1 μg/mL respectively. In-silico ADMET studies reveal that the toxicity, bioactivity, pharmacokinetics and drug-likeness properties of Limonia acidissima leaf extract is good. The molecular docking studies show that the microbial activity is high for Bacillus subtilis and Candida albicans showing the coincidence of the in silico and in vitro studies as expected. The free radical scavenging activity of nanoparticles is 80 for 100 μg/mL. The 50% of inhibition of silver nanoparticles against human breast cancer cell lines is 18 μg/mL. It is evident that silver nanoparticles would be helpful in treating cancer cell lines and have great perspectives in the biomedical sector.
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    LIRIOPE PLATYPHYLLA EXTRACT AS A GREEN INHIBITOR FOR MILD STEEL CORROSION IN SULFURIC ACID MEDIUM
    (Taylor & Francis Online, 2021) Ill-Min, Chung; Venkatesan, Hemapriya; Seung-Hyun, Kim; Kanchana, Ponnusamy; Natarajan, Arunadevi; Subramanian, Chitra
    The phytochemical components of the methanol extract of Liriope platyphylla (L. platyphylla) leaves were identified using UHPLC, and their antioxidant activities were studied. The impact of the L. platyphylla extract on the corrosion of mild steel by 1 M H2SO4 was assessed using electrochemical and gravimetric techniques. L. platyphylla exhibited concentration-dependent corrosion protection activity through a mixed-mode adsorption process, as revealed by polarization studies. Impedance measurements indicated the development of a protective film of the inhibitor, which was confirmed by morphology studies at the micro level with scanning electron microscopy (SEM) and at the nano level with atomic force microscopy (AFM). Fourier transform infrared (FT-IR) studies also confirmed the adsorption of the inhibitor film onto the mild steel surface.
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    INHIBITORY EFFECT OF BIOWASTE ON COPPER CORROSION IN 1 M HCL SOLUTION
    (Elsevier, 2021-05) Venkatesan, Hemapriya; Ill-Min, Chung; Seung-Hyun, Kim; Mayakrishnan, Prabakaran
    The potential of human hair extract (HRE), a biodegradable biowaste extract, to protect copper surface and inhibit metallic corrosion in 1 M HCl was investigated using electrochemical and weight loss techniques. The results revealed that HRE exhibits an efficient corrosion-mitigating effect via adsorption onto the metal surface following a Langmuir isotherm. A maximum inhibition efficiency (IE %) of 92.47 % was achieved using 100 ppm of the HRE inhibitor. Tafel plot results revealed the mixed-mode corrosion protection behavior of HRE. Surface analysis using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and atomic force microscopy (AFM) provided evidence for the precipitation of a protective HRE film on the metal surface. The interaction of HRE with copper was investigated using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) spectroscopy; they confirmed the above conclusions.
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    FLOXACINS: AS MEDIATORS IN ENHANCING THE CORROSION INHIBITION EFFICIENCY OF NATURAL POLYMER DEXTRIN
    (Springer Link, 2020-01-11) Gowraraju, Nirmala Devi; Chan, Basha Nusrath Unnisa; Selvaraj, Mohana Roopan; Venkatesan, Hemapriya; Subramanian, Chitra; Ill-Min, Chung; Seung-Hyun, Kim; Mayakrishnan, Prabakaran
    Three different floxacins (Ciprofloxacin, Levofloxacin, and Norfloxacin) were used to enhance the inhibition property of Dextrin (Dex) against the dissolution of mild steel in acid medium. Substantial increase in the inhibition property was observed against mild steel dissolution by the addition of floxacins than with pure Dex. Weights loss experiments proved the potential of Fluoroquinolones (FQs) in enhaning the corrosion inhibition property of Dex on metal by proving its best ability at lower concentrations. Adsorption of Dex and floxacins on metal surface was observed to accept with Langmuir adsorption isotherm. The results from EIS studies add to the enhancing property of floxacins on Dex. While the mixed type behavior of inhibitors were confirmed by polarization studies, images from SEM, EDS and AFM gathers strength to propose the formation of protective layer.
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    ANTI-CORROSIVE POTENTIAL OF CYPERUS ROTUNDUS AS A VIABLE CORROSION INHIBITOR FOR MILD STEEL IN SULPHURIC ACID
    (Emerald Publishing Limited, 2020-06-05) Rajan, Anitha; Chan Basha, Nusrath Unnisa; Venkatesan, Hemapriya; Selvaraj, Mohana Roopan; Subramanian, Chitra; Chung, ll-Min; Seung-Hyun, Kim; Prabakaran, Mayakrishnan
    Over the past decade, plant extracts are ultimate green candidatures to substitute the expensive and noxious synthetic corrosion inhibitors. In this regard, this study aims to focus on evaluating anti-corrosion properties of green inhibitor Cyperus rotundus (C. rotundus), a perennial herb found throughout India.
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    INHIBITION OF MILD STEEL CORROSION USING MAGNOLIA KOBUS EXTRACT IN SULPHURIC ACID MEDIUM
    (Elsevier, 2020-12) Ill-Min, Chung; Ramalingam, Malathy; Rameshkumar, Priyadharshini; Venkatesan, Hemapriya; Seung-Hyun, Kim; Mayakrishnan, Prabakaran
    Magnolia kobus DC. (M. kobus), a prominent Southeast Asian flowering plant species, was investigated for its inhibition efficiency against mild steel corrosion in 1 M H2SO4. The extract (M. kobus) was identified to have 145.80 μg/g of myricetin and 102.32 μg/g syringic acid as prominent components, with a total phenolic content (TPC) of 95.26 mg/g and a total flavonoid content (TFC) of 25.38 mg/g. The mass-loss measurements showed that 500 ppm of M. kobus extract was able to inhibit corrosion, with an efficiency of 95.01% at 303 ± 1 K. Reduction of dissolved iron content in the inhibited solution than in the inhibitor free solution observed in Atomic Adsorption Spectroscopy (AAS) revealed the corrosion mitigating effect of inhibitor on mild steel. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) analysis of the protected and unprotected mild steel samples indicate adsorption of M. Kobus on the electrode surface. UV–vis and FT-IR studies complement the above results. The electrochemical studies indicated that M. kobus functioned as a mixed-type indicator and myricetin along with other plant components present in the plant extract contributed to the inhibition process.
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    UTILIZATION OF BIOWASTE AS AN ECO-FRIENDLY BIODEGRADABLE CORROSION INHIBITOR FOR MILD STEEL IN 1 MOL/L HCL SOLUTION
    (Elsevier, 2020-12) Venkatesan, Hemapriya; Mayakrishnan, Prabakaran; Subramanian, Chitra; Manoharan, Swathika; Seung-Hyun, Kim; Ill-Min, Chung
    This report focuses on the application of a biodegradable biowaste [human hair-(HHR)], to produce a mild steel corrosion inhibitor. The performance of HHR extract in inhibiting metallic corrosion in 1 mol/L HCl was investigated. The analysis of the metal corrosion behavior using electrochemical and weight loss techniques revealed that HHR exhibits an efficient corrosion-mitigating effect via adsorption on the metal surface following a Langmuir isotherm. Tafel-plot results revealed the mixed-mode corrosion protection behavior of HHR. Surface analysis using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and Fourier transform infrared (FT-IR) spectroscopy provided evidence for the precipitation of a protective HHR film on the metal surface.