International Journal

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    CURRENT STATUS OF MICROBES INVOLVED IN THE DEGRADATION OF PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) POLLUTANTS IN THE AQUATIC ECOSYSTEM
    (Elsevier, 2022-05-01) Mathiyazhagan, Narayanan; Mostafa, El-sheekh; Ying, Ma; Arivalagan, Pugazhendhi; Devarajan, Natarajan; Gajendiran, Kandasamy; Rathinam, Raja; Saravana Kumar, R.M; Suresh, Kumarasamy; Govindasamy, Sathiyan; Geetha, R; Balaji, Paulraj; Guanglong, Liu; Sabariswaran, Kandasamy
    Contamination of aquatic systems with pharmaceuticals, personal care products, steroid hormones, and agrochemicals has been an immense problem for the earth's ecosystem and health impacts. The environmental issues of well-known persistence pollutants, their metabolites, and other micro-pollutants in diverse aquatic systems around the world were collated and exposed in this review assessment. Waste Water Treatment Plant (WWTP) influents and effluents, as well as industrial, hospital, and residential effluents, include detectable concentrations of known and undiscovered persistence pollutants and metabolites. These components have been found in surface water, groundwater, drinking water, and natural water reservoirs receiving treated and untreated effluents. Several studies have found that these persistence pollutants, and also similar recalcitrant pollutants, are hazardous to a variety of non-targeted creatures in the environment. In human and animals, they can also have severe and persistent harmful consequences. Because these pollutants are harmful to aquatic organisms, microbial degradation of these persistence pollutants had the least efficiency. Fortunately, only a few wild and Genetically Modified (GMOs) microbial species have the ability to degrade these PPCPs contaminants. Hence, researchers have been studying the degradation competence of microbial communities in persistence pollutants of Pharmaceutical and Personal Care Products (PPCPs) and respective metabolites for decades, as well as possible degradation processes in various aquatic systems. As a result, this review provides comprehensive information about environmental issues and the degradation of PPCPs and their metabolites, as well as other micro-pollutants, in aquatic systems.
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    THE PHARMACEUTICAL POTENTIAL OF CRUDE ETHANOL LEAF EXTRACT OF PEDALIUM MUREX (L.)
    (Elsevier, 2022) Mathiyazhagan, Narayanan; Arunachalam, Kiran; Devarajan, Natarajan; Sabariswaran, Kandasamy; Sabarathinam, Shanmugam; Maha, Alshiekheid; Hesham S, Almoallim; Arivalagan, Pugazhendhi
    The purpose of this study was to determine the antibacterial competence of various solvent leaf extracts of Pedalium murex against bacteria that cause skin infections such as Staphylococcus aureus, (folliculitis), Streptococcus pyogenes (impetigo), and Corynebacterium sp. (pitted keratolysis). The presence of phytochemicals, antioxidant activity, and cytotoxicity on the Human Embryonic Kidney (HEK 293) cell line were also studied. The ethanol extract contained more phytochemical ingredients (saponins, flavonoids, alkaloids, terpenoids, phenolics, quinones, and betacyanin) than the other extracts. An increased concentration of ethanol extract demonstrated excellent antibacterial activity (zone of inhibition) against bacteria such as S. aureus, S. pyogenes, and Corynebacterium sp. and it followed by methanol extract. This is the first report on the antibacterial activity of an ethanol extract of P. murex against bacteria that cause skin infections. The average minimum inhibitory concentration (MIC) value of ethanol extract was found as 13.64 mg mL−1. In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl free radical scavenging assay, the crude ethanol (87.25 and 83.24 % respectively) and methanol extracts (81.41% and 78.39% respectively) showed excellent antioxidant activity. The cytotoxicity study (4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) revealed that the crude ethanol extract of P. murex effectively supported the proliferation of HEK 293 cell line with the absence of considerable number of cell death even at 500 mg mL−1. The findings concluded that the components present in the ethanol extract could be used in drug formulations to combat bacteria that cause skin infections without causing side effects.