Browsing by Author "S, Nagarajan"

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FACILE SYNTHESIS OF 2-AMINO-5,6,7,8-TETRAHYDRO-5,7-DIARYLPYRIDO[4,3-D]PYRIMIDIN-4-OLS
(Taylor & Francis, 2009-08-12) P, Amutha; S, Nagarajan
2-Amino-5,6,7,8-tetrahydro-5,7-diarylpyrido[4,3-d]pyrimidin-4-ols were synthesized from various ethyl 2,6-diaryl-4-oxopiperidin-3-carboxylates with guanidine hydrochloride in presence of sodium ethoxide.
SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME 2-AMINO-4-(1, 1′-BIPHENYL-4-YL)-6-ARYL-6H-1, 3-THIAZINES
(Journal of Sulfur Chemistry, 2007-02-01) N, Ingarsal; P, Amutha; S, Nagarajan
A series of new 2-amino-4-(1,1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines has been synthesized, characterized by IR, 1H NMR, 13C NMR, mass and elemental analyses and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that the compounds had better activity against tested organisms than the reference norfloxacin.
SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME 2-AMINO-4-(1,1'-BIPHENYL-4-YL)-6-ARYL-6H-1,3-THIAZINES
(Taylor & Francis, 2007-02-01) N, Ingarsal; P, Amutha; S, Nagarajan
A series of new 2-amino-4-(1,1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines has been synthesized, characterized by IR, 1H NMR, 13C NMR, mass and elemental analyses and evaluated for in-vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that the compounds had better activity against tested organisms than the reference norfloxacin.
SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NEW 4,6‐DIARYL‐ 4,5‐DIHYDRO‐3‐HYDROXY‐2H‐INDAZOLES
(Wiley, 2011-12-19) P, Amutha; S, Nagarajan
A series of new 4,6-diaryl-4,5-dihydro-3-hydroxy-2H-indazoles 5a–5k were synthesized by the cyclization of ethyl 2-oxo-4,6-diarylcyclohex-3-ene carboxylates 4a–4k. The compounds were characterized by IR, 1 H NMR, 13C NMR, 2D NMR, and elemental analysis. The synthesized compounds were evaluated for in vitro antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger, Aspergillus flavus, and Rhizopus sp. Most of the compounds exhibited good activity against the tested organisms.
SYNTHESIS AND STEREODYNAMICS OF N-FORMYL-1,2,3- SELENADIAZOLOPYRIDINES
(Taylor & Francis, 2012-01-31) M, Ingarsal; P, Amutha; M, Gopalakrishnan; S, Nagarajan
The 4,6-diaryl-6,7-dihydro-[1,2,3]selenadiazolo[5,4-c]pyridine-5(4H)-carbalde hydes were synthesized from 2,6-diarylpiperidin-4-ones and characterized using infrared, 1H, 13C Nuclear Magnetic Resonance (NMR), and mass spectroscopic techniques. On the NMR time scale, the compounds exist in syn and anti isomeric forms. Separate signals were obtained for isomers in the NMR spectra. The compounds’ stereodynamic nature was studied based on the intensity and position of NMR signals
SYNTHESIS OF NOVEL SPIROPYRIMIDINONES
(Wiley, 2010-03-11) P, Amutha; S, Nagarajan
An efficient one-pot synthesis of new spirocyclic 2-aminopyrimidinones via the three-component reaction of a cyclic ketone, alkyl cyanoacetate, and guanidinium carbonate was developed via a domino reaction
SYNTHESIS, IN VITRO ANTIBACTERIAL AND ANTIFUNGAL EVALUATIONS OF 2-AMINO-4-(1-NAPHTHYL)-6-ARYLPYRIMIDINES
(Elsevier, 2007-04) N, Ingarsal; G, Saravanan; P, Amutha; S, Nagarajan
A series of 2-amino-4-(1-naphthyl)-6-arylpyrimidines have been synthesized and characterized by IR, NMR, MS, elemental analyses and evaluated for in vitro antibacterial and antifungal activities. Some of the compounds were found to be active against a limited panel of bacteria and fungi. In particular, compounds 4b and 4e were found to be the most effective analogs against the tested bacterial and fungal strains