National Journals

Permanent URI for this collectionhttps://dspace.psgrkcw.com/handle/123456789/2989

Browse

Start date: 2010End date: 2019

Search Results

Now showing 1 - 8 of 8
  • No Thumbnail Available
    Item
    A REVIEW ON LOW TEMPERATURE COMBUSTION ENGINES: PERFORMANCE, COMBUSTION AND EMISSION CHARACTERISTICS
    (Elsevier, 2019-12) Krishnamoorthi, M; Malayalamurthi, R; Zhixia, He; Sabariswaran, Kandasamy
    Low temperature combustion (LTC) is a recent engine technology that can reduce the oxides of nitrogen (NOx) and soot emissions simultaneously while maintaining higher thermal efficiency. The present review work investigates the performance, emission and combustion characteristics of LTC mode engines. Partially premixed LTC (PPLTC), homogeneous charge compression ignition (HCCI), premixed charge compression ignition (PCCI) and reactivity controlled compression ignition (RCCI) modes are researched under LTC mode. In recent decades, different engine strategies have been employed to reduce exhaust emissions and to enhance thermal efficiency. Exhaust gas recirculation, variable valve timing (VVT), advanced fuel injection technologies are adapted to achieve LTC mode in internal combustion (IC) engines to get improved outcomes. This review highlights the properties of fuels, fuel supply systems, valve actuation mechanisms, engine operating conditions and its effects on the engine characteristics. This review provides a perspective plan to the researchers for enhancing the performance, emission and combustion behavior of an engine by using LTC mode with lower NOx and soot emissions. Among LTC mode engines, RCCI mode engine operates well in 60% load, 60% premixed ratio, 35:1 air-fuel ratio and 56% brake thermal efficiency within the combustion phasing control.
  • No Thumbnail Available
    Item
    IMPROVEMENT OF EMISSION REDUCTION IN NANO ADDITIVE SIMAROUBA GLAUCA BIODIESEL BLENDS
    (Taylor & Francis Online, 2018-06-26) Sabariswaran, Kandasamy; Selvakumar, Sundararaj
    In this paper discussed about the emission profile from nano additive blended biodiesel. It is observed that minimum carbon dioxide was emitted in the presence of zinc oxide blends when compared to B20 and diesel. The hydrocarbon emission for the diesel and B20 was higher than that of the B20ZnO50 and B20ZnO100 blended fuels. The higher oxide of nitrogen emissions was observed with the B20ZnO50 and B20ZnO100 blended fuels at all engine loads when compared to B20 and diesel.
  • No Thumbnail Available
    Item
    N-GLYCAN MATURATION IS CRUCIAL FOR CYTOKININ-MEDIATED DEVELOPMENT AND CELLULOSE SYNTHESIS IN ORYZA SATIVA
    (Pub Med, 2013-02-25) Wahyu, Indra Duwi Fanata; Kyoung, Hwan Lee; Bo, Hwa Son; Jae, Yong Yoo; Rikno, Harmoko; Ki, Seong Ko; Nirmal Kumar, Ramasamy; Kyung, Hwa Kim; Doo, Byoung Oh; Hyun, Suk Jung; Jae, Yean Kim; Sang, Yeol Lee; Kyun, Oh Lee
    To explore the physiological significance of N-glycan maturation in the plant Golgi apparatus, gnt1, a mutant with loss of N-acetylglucosaminyltransferase I (GnTI) function, was isolated in Oryza sativa. gnt1 exhibited complete inhibition of N-glycan maturation and accumulated high-mannose N-glycans. Phenotypic analyses revealed that gnt1 shows defective post-seedling development and incomplete cell wall biosynthesis, leading to symptoms such as failure in tiller formation, brittle leaves, reduced cell wall thickness, and decreased cellulose content. The developmental defects of gnt1 ultimately resulted in early lethality without transition to the reproductive stage. However, callus induced from gnt1 seeds could be maintained for periods, although it exhibited a low proliferation rate, small size, and hypersensitivity to salt stress. Shoot regeneration and dark-induced leaf senescence assays indicated that the loss of GnTI function results in reduced sensitivity to cytokinin in rice. Reduced expression of A-type O. sativa response regulators that are rapidly induced by cytokinins in gnt1 confirmed that cytokinin signaling is impaired in the mutant. These results strongly support the proposed involvement of N-glycan maturation in transport as well as in the function of membrane proteins that are synthesized via the endomembrane system.
  • No Thumbnail Available
    Item
    EVALUATION OF ARTOCARPUS HIRSUTUS FRUIT PULP AGAINST ALZHEIMER'S DISEASE
    (2013-08-31) M., Jeyam; R., Peelaja Rani; G., Shalini; P., Ravikumar
    The present study was aimed to identify the phytoconstituents from the methanolic extract of Artocarpus hirsutus fruit pulp using GC-MS analysis and dock the selected compounds with Acetylcholinesterase, a key target in the treatment of Alzheimer's Disease (AD). From the results of the selected compounds, Ethyl oleate showed better interaction with Acetylcholinesterase which had a better Glide Score of -7.5 Kcal/mol followed by Pentacosanoic acid, methyl ester (-6.7Kcal/mol), Methyl petroselinate (-6.1Kcal/mol), 3-Methyl-3-nonanol (- 5.8Kcal/mol), 2,2-Dimethylpropyl2,2-dimethyl propane sulfinylsulfone (-5.8 Kcal/mol), Methyl tricosaoate (-5.8Kcal/mol) when compared to the synthetic drug Rivastigmine (-5.6Kcal/mol). Further in vitro analysis of methanolic extract proved its high efficiency for antioxidant activity (DPPH radical scavenging activity (90.80%), TPC (7.36±0.06), Reducing power ability (75.16±0.31)). The results of the study clearly indicates that Artocarpus hirsutus fruit pulp can be added as a food supplement to reduce the risk of several diseases related to oxidative stress, especially AD.
  • No Thumbnail Available
    Item
    IN SILICO SCREENING OF PHYTOCOMPOUNDS TO TARGET MALARIAL PLASMEPSIN II USING DOCKING ANALYSIS
    (2011-07-01) Muthusamy, Jeyam; Periyasamy, Shanthi; Palanisamy, Ravikumar; Ganeshan, Shalini
    Malaria, a global disease affecting 300-500 million and resulting in death of one to two million people annually, is caused by the protozoa, Plasmodium. The most deadly species Plasmodium falciparum is becoming increasingly resistant to drugs and it becomes essential to find out new antimalarial agents. Haemoglobin degradation is a parasite specific catabolic process and is very essential for the survival of parasite inside the human body. Two asparatic proteases from Plasmodium falciparum, Plasmepsin (Plm) I and II, initiate the degradation of haemoglobin. In this study, the haemoglobin degrading enzyme Plasmepsin II had been used as the target macromolecule. The phytocompounds and the synthetic drugs were docked in the active site of Plasmepsin II using glide software. Docked compounds were ranked according to the glide values and it was concluded that 6 natural compounds showed better results than the drugs and can be used against malarial Plasmepsin II.
  • No Thumbnail Available
    Item
    EVALUATING MULTI-TARGET EFFICIENCY OF PHYTOCOMPOUNDS AGAINST DIABETES MELLITUS - AN IN SILICO APPROACH
    (BIOINFO Drug Targets, 2014-05-29) Jeyam M; Priyadharshini K; Ravikumar P; Shalini G
    Diabetes mellitus (DM) is a complex mulitifactorial metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. In the present study, the phytocompounds were selected from traditionally used medicinal plants and nutraceuticals and the selected targets for Diabetes Mellitus were Peroxisome Proliferator Activate Receptor gamma, Fructose 1-6 bisphosphate and Dipeptidyl peptidase IV. Using Glide (Schrodinger module), in silico docking of the phytocompounds with these targets was carried out and their efficacy was evaluated against DM. The docking results of the phytocompouds were compared with the corresponding synthetic drugs in order to explore the multi -targeting efficiency of the phytocompounds for treating diabetes. Of the 27 selected compounds from 12 plants, Glucobrassicin present in Capparis spinosa and Brassica oleracea (Broccoli) and Epigallocatechin gallate (EGCG) present in Camellia sinensis showed better interactions and glide score with all the 3 receptors than the corresponding drugs / inhibitor. From the present study it is concluded that the phytocompounds can be used as an appropriate lead molecules against diabetes. Further the nutraceuticals, Aegle marmelos, Brassica oleracea, Glycine max, Zingiber officinale, Capparis spinosa and Trigonella foenum graecum can be added as food supplement to reduce the risk of diabetes
  • No Thumbnail Available
    Item
    PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF WHEAT GRAINS AND SEEDLINGS
    (Journal of Pharmaceutical and Scientific Innovation, 2014) Ravikumar P; Shalini G; Jeyam M
    The phytochemical profiles and antioxidant activity of methanolic extract of Wheat Grains (WG) and 3 days old wheat seedlings (3dWS) were evaluated in the present study. Phytochemical analysis was performed for alkaloids, flavonoids, phenols, saponins, steroids, terpenoids, proteins and carbohydrates in WG and 3dWS extracts. Antioxidant activity was evaluated using DPPH and ABTS radical scavenging activity, total phenolic content and reducing power ability. In this study, the results of WG were compared with 3dWS. The results of phytochemical analysis showed the presence of all the above phytochemicals in the both 3dWS and WG extracts. When compared with WG, the 3dWS possesses high nutritional contents and antioxidant activity. Hence, it is suggested to add wheat seedling in the daily diet to reduce many diseases caused by antioxidant deficiency.
  • No Thumbnail Available
    Item
    COMPUTATIONAL ANALYSIS OF PHYTOCOMPOUNDS WITH 1, 3 - Β-D-GLUCAN SYNTHASE FOR ANTIDERMATOPHYTIC ACTIVITY
    (2014-02-27) M, Jeyam; M, Arangaraj; P, Ravikumar; G, Shalini
    Skin diseases are the most common infection in humans as well as in animals caused by fungi like yeast, mould and dermatophytes. In this study, in silico analysis of 20 phytocompounds was carried out for their efficacy as antidermatophytic agents using the receptor 1, 3 - β -D-Glucan synthase. The 3D structure of the receptor obtained using Modeller9V8 was validated with Procheck, where Ramachandran plot showed 80.3% of residues in the most favoured region. The phytocompounds and the drugs Echinocandin B and Caspofungin were docked with 1, 3 - β -D-Glucan synthase using Glide. Though all the 20 compounds exhibited lesser energy than both Echinocandin B (-3.3Kcal/mol) and Caspofungin (-1.68 Kcal/mol), Quercetin-3-O-rutinoside exhibited very less energy (-11.56 Kcal/mol). Further, comparing to synthetic drugs, the entire compounds selected for this study showed high interaction with the modeled protein. Hence, the present study concludes that the efficacy of all phytocompounds used in this study act against dermatophyes and which will be very helpful to the researchers working in the area of dermatophye drug developments