International Journals

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Author: search.filters.author.Pream Sudha VSubject: search.filters.subject.Autism Spectrum Disorder

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    PREDICTION OF GENE SUSCEPTIBILITY TO AUTISM SPECTRUM DISORDER USING DEEP ARCHITECTURES
    (International Journal of Scientific and Technology Research, 2020) Pream Sudha V; Vijaya M.S
    A genetic predisposition or susceptibility to Autism Spectrum Disorder (ASD) is an increased likelihood of developing it based on the genetic makeup of a person. The multiple variants found in each gene have their own probability of associated risk and so the major problem lies in the systematic evaluation of their functional significance to ASD. Hence it is essential to develop methods for quantitative evaluation of ASD candidate genes with co-occurring mutations which will provide a clear understanding of their relevance to ASD. This research work deals with the development of a discriminative model for prioritization of candidate genes considering mutations in them and to classify them based on their predisposition to the disorder. The model for gene susceptibility prediction is built by integrating the combined potential of substantiation for each ASD linked gene and the related mutations. In this research work gene susceptibility prediction is modelled as a pattern classification problem and deep learning techniques are employed to build the models. The performance evaluation of these models proves that Long Short Term Memory (LSTM) based gene susceptibility prediction model has shown better performance.
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    DEEP LEARNING BASED PREDICTION OF AUTISM SPECTRUM DISORDER USING CODON ENCODING OF GENE SEQUENCES
    (International Journal of Engineering and Advanced Technology, 2019) Pream Sudha V; Vijaya M S
    The development of computational tools to recognize Autism Spectrum Disorder (ASD) originated by genetic mutations is vital to the development of disease-specific targeted therapies. Identifying genes causing the genetically transmitted ASD is still a challenging task. As genomics data is dependent on domain specific experts for identifying efficient features and extracting hand-crafted attributes involves much time, an alternate effective solution is the need of the hour. The rapid developments in the design of deep architecture models have led to the broad application of these models in a variety of research areas and they have shown considerable success in sequential data processing tasks. The primary goal of this work is to classify the ASD gene sequences by employing a Deep Neural Network based model. This in turn will enable effective genetic diagnoses of this disease and facilitate the targeted genetic testing of individuals. This work utilizes codon encoding and one hot encoding technique to transform the mutated gene sequences which are exploited for self learning the features by deep network. Experiments showed that the performance of the proposed model was better than that of the conventional Multilayer Perceptron with promising accuracy of 77.8%, 80.1% and 81.2% for three different datasets.