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    Diagnosis of Diabetes Mellitus using Bayesian Network
    (Sri Venkateswara Eductional Trust, 2015-01) J, Maria Shyla
    Diabetes mellitus, simply referred to as diabetes, is a group of metabolic diseases.There exists more than one type of diabetes, with each type having its own risks.Diabetes is ascribed to the acute conditions under which the production and consumption of insulin is disturbed in the body which consequently leads to the increase of glucose level in the blood. Bayesian networks are considered as helpful methods for the diagnosis of many diseases. They, in fact, are probable models which have been proved useful in displaying complex systems and showing the relationships between variables in a graphic way. The advantage of this model is that it can take into account the uncertainty and can get the scenarios of the system change for the evaluation of diagnosis procedures. In this study, decision tree and Bayesian models have been compared. The results indicated that the Bayesian model is much more accurate in diabetes diagnosis.
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    PPI RECONSTRUCTION TO PRIORITIZE CANDIDATE GENE WITH MULTI OBJECTIVE BAT ALGORITHM
    (Coimbatore Institute of Information Technology / Nehru Arts and Science College, 2018-11-26) J, Maria Shyla; M, Renuka Devi
    Candidate gene prioritization is the process of identifying new genes as potential candidates of being associated with a disease. A random walk-based algorithm called Random Walker on the Reliable Heterogeneous Network (RWRHN) was used to prioritize potential candidate genes for inherited disease. In this paper, the prioritization of candidate gene is improved by considering the gene similarity along with the topological similarity and phenotype similarity. Then, the similarity of genes of proteins is calculated based on gene expression data. A sub space clustering is obtained by utilizing multi objective BAT algorithm. Based on topological similarity matrix and gene similarity the PPI network is reconstructed. Finally RWRHN is applied to prioritize potential candidate genes. Thus the prioritization of candidate gene is improved with the consideration of gene similarity.