Browsing by Author "Velmurugan R"

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CO(II) COMPLEX OF 2-AMINO-6-METHYLBENZOTHIAZOLE: SYNTHESIS, STRUCTURE AND BIOLOGICAL EVALUATION
(NISCAIR-CSIR, India, 2016-11) Jone, Kirubavathy S; Velmurugan R; Karvembu R; Bhuvanesh N.S.P; Enoch I V M; Selvakumar V; Mosae P; Chitra S
Cobalt(II) complex of 2-amino-6-methylbenzothiazole has been synthesized and characterized by various physico-chemical methods. The ligand 2-amino-6-methylbenzothiazole acts as monodentate, neutral ligand with N as the donor site. The molecular structure of the title complex has been determined by single crystal X-ray diffraction studies. The Co(II) complex shows significant antioxidant activity against DPPH radical. The complex shows cytotoxicity with a IC50 value of 14.12 µM against MCF-7 cell line. In addition, the complex shows good antimicrobial and anti-tuberculosis activities against various microbes and mycobacterium tuberculosis respectively. DNA binding of the title complex has been investigated by absorption spectroscopic technique, which reveals that the complex acts as minor groove binder. These results have been validated by molecular docking studies.
STRUCTURAL AND MOLECULAR DOCKING STUDIES OF BIOLOGICALLY ACTIVE MERCAPTOPYRIMIDINE SCHIFF BASES
(Elsevier, 2017-01-05) JoneKirubavathy S; Velmurugan R; Karvembu R; Bhuvanesh N S P; Enoch I V M N; MosaeSelvakumar P; Premnath D; Chitra S
Novel Schiff bases derived from the treatment of mercapto-diamino pyrimidine with two different aldehydes are characterized using elemental analysis, single crystal X-ray diffraction and 1H NMR spectroscopy. The pharmacological action of the synthesized compounds viz., antimicrobial, anticancer and antitubercular activities is studied. The Schiff bases show a very good activity against various test pathogens. DNA and β-CD binding interactions of the compounds are studied using UV–Visible absorption and fluorescence spectral measurements. The binding constants of the compounds towards β-CD are in the order of 103 to 104. Molecular docking is done using MOE program on the 3D structure of the enzymes, viz., human thymidylate synthase complexed with dump and raltitrex, candida albicans N-myristoyltransferasepeptidic inhibitor, catalytic domain of protein kinase pKnb from mycobacterium tuberculosis in complex with mitoxantrone, pare, topoisomerase atpase inhibitor, E. coli and lactobacillus casdihydrofolatereductase. The MIC/IC50 values of the Schiff bases are compared with the glide scores from the molecular docking studies. The number of hydrogen bonding interactions between the Schiff bases and amino acid residues are also reported.
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF CU (II) AND VO (IV) COMPLEXES OF 2, 3- DIPHENYLQUINOXALINE
(International Journal of recent scientific research, 2014) Jone Kirubavathy S; Velmurugan R; Parameswari K; Chitra S
A new series of transition metal complexes of Cu(II) and VO(IV) were synthesized from the ligand 2,3-diphenyl quinoxaline. The structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis, 1H-NMR and ESR spectral studies. The data show that the Cu (II) and VO(IV) complexes are of ML2 type . The UV-Vis., magnetic susceptibility and ESR spectral data suggests a square planar geometry for Cu (II) complex and a square pyramidal geometry for VO(IV) complex. The antimicrobial screening tests were also recorded and gave good results in the presence of ligand system with the metal.
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF CU(II), CO(III) AND FE(III) COMPLEXES OF 2-BENZOYL-3-(NITROPHENYL)QUINOXALINE
(International Journal of Pharmaceutical Sciences and Research, 2014-05-01) JoneKirubavathy S; Velmurugan R; Parameswari K; Chitra S
A new series of transition metal complexes of the type ML where M = Cu(II), Co(III) and Fe(III) and L = 2-benzoyl-3-(nitrophenyl)quinoxaline have been characterized and the structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis and NMR spectral data. From the spectral measurements and magnetic susceptibility values a square planar geometry was proposed for Cu(II) complex and an octahedral geometry for Co(III) and Fe(III) complexes. The qualitative and quantitative antimicrobial activity test results proved that all the prepared complexes are very active especially against E. coli, S. aureus, C. albicans and A. niger.
SYNTHESIS, CHARACTERIZATION, SINGLE CRYSTAL XRD AND PHARMACOLOGICAL EVALUATION OF CU(II), CO(II), NI(II) AND ZN(II) COMPLEXES OF 2,3-DIFURYLQUINOXALINE
(Journal of Chemical and Pharmaceutical research, 2015) JoneKirubavathy S; Velmurugan R; Parameswari K; Chitra S
The transition metal complexes Cu(II), Co(II), Ni(II) and Zn(II) of 2, 3-difuryl quinoxaline have been synthesized and characterized by various physico-chemical techniques viz. elemental analysis, magnetic moment, IR, NMR, TGA, Single crystal XRD and electronic studies. The complexes have found a stoichiometry of 1:2 (M : L), wherein nitrogen in the quinoxaline ring and oxygen in the furyl ring is co-ordinated to the metal. These studies revealed an octahedral geometry for Cu(II) and Co(II) complexes and a square planar geometry for Ni(II) and Zn(II) complexes. The ligand and its complexes were screened for their antibacterial activity against gram positive bacteria and gram negative bacteria namely B. subtilis, S. aureas, E. coli , K. pneumoniea respectively by the disc diffusion method and antifungal activity against M. rubram, A. niger and C. albicans and found to be good. The in-vitro anti cancer activity of the single crystal 2, 3-difurylquinoxaline and its Co(II) complex was screened against the human breast cancer cell line HeLa and the IC50 values are 90.19 and 20.25µg/ml respectively
SYNTHESIS, CHARACTERIZATION, SINGLE CRYSTAL XRD, IN VITRO ANTIMICROBIAL AND CYTOTOXICITY STUDY OF TRIS(ETHYLENEDIAMINE)COBALT(III)CHLORIDE OXALATE TRIHYDRATE
(Arabian Journal of Chemistry, Elsevier, 2019) JoneKirubavathy S; Velmurugan R; Parameswari K; Chitra S
The complex tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate [Co(en)3] Cl(C2O4)Æ3H2O crystallizes in the monoclinic space group C2/c with the following unit cell parameters a = 19.9318 (13), b = 9.3344 (4), c = 19.0881 (13) A˚ b = 96.846(3), Z = 8. The crystal structure was solved by direct methods and refined by full matrix least squares procedures to a final R value of 0.0314 for 4330 observed reflections. The reported cobalt complex is six co-ordinated through amine nitrogen with distorted octahedral geometry. There are uncoordinated chloride and oxalate ions along with the water molecules. In-vitro antimicrobial activity was studied against various test organisms and found to be good. From in-vitro cytotoxic activity of the synthesized complex, the IC50 value was found to be 55.85 lg/ml
SYNTHESIS, CHARACTERIZATION, SINGLE-CRYSTAL XRD, AND BIOLOGICAL EVALUATION OF NICKEL(II) SALEN SULFADIAZINE COMPLEX
(Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, Taylor and Francis, 2016) Jone Kirubavathy S; Velmurugan R; Tamilarasan B; Karvembu R; Bhuvanesh N S P; Chitra S
Nickel(II) Salen sulfadiazine complex was prepared and characterised by the spectral studies such as FT-IR, UV-Vis and NMR, and single-crystal XRD. The nickel(II) complex was screened for in vitro antimicrobial activities against various test organisms Aeromonashydrophila, Serratiamarcescens, Bacillus licheniform, Pseudomonas aeruginosa, Acinetobacterbaumanii, Aspergillusniger, and Candida albicans by the well diffusion method and in vitro anticancer activity against the human breast cancer cell line HeLa. The NiO obtained by the thermal decomposition of Ni (salen) sulfadiazine complex was characterised using TEM images and their SAED pattern
SYNTHESIS, STRUCTURE, AND PHARMACOLOGICAL EVALUATION OF CO(III) COMPLEX CONTAINING TRIDENTATE SCHIFF BASE LIGAND
(Springer, 2015-05-07) JoneKirubavathy S; Velmurugan R; Karvembu R; Bhuvanesh N S P; Parameswari K; Chitra S
A Co(III) Schiff base complex with the formula [Co(L)2]Cl • H2O (I) (L = monoanionic tridentate Schiff base ligand derived from salicylaldehyde and ethylene diamine) has been synthesized and characterized by elemental analysis and spectroscopic techniques. The structure of I was confirmed by single crystal X-ray diffraction studies (CIF file CCDC no. 1009967), which showed the presence of two Schiff base molecules in an octahedral fashion. The complex has been screened for its in vitro antibacterial and anticancer activities. Complex I was found to be more active in anti-microbial and anti-cancer activity than the ligand.