Browsing by Author "Thangaraj, Arasakumar"

Filter results by typing the first few letters
Now showing 1 - 5 of 5
  • No Thumbnail Available
    Item
    ONE-POT APPROACH TO PYRIDO-4-PHENANTHRIDINONES BY PALLADIUM-CATALYZED ANNULATION OF 4-QUINOLONES WITH 2-BROMOBENZYL BROMIDES
    (Synlett, 2018-11-28) Thangaraj, Arasakumar; Selvaraj, Shyamsivappan; Subashini, Gopalan; Athar, Ata; Palathurai, Subramaniam Mohan
    A straightforward approach toward the assembly of phenanthridinone heterocycles has been developed through the palladium-catalyzed N-benzylation/intramolecular coupling reactions of readily prepared 4-quinolones with commercially available 2-bromobenzyl bromide derivatives. The target products were prepared in moderate to good yields, with tolerance of various functional groups.
  • Thumbnail Image
    Item
    SYNTHESIS AND X-RAY STUDY OF DISPIRO 8-NITROQUINOLONE ANALOGUES AND THEIR CYTOTOXIC PROPERTIES AGAINST HUMAN CERVICAL CANCER HELA CELLS
    (The Royal Society of Chemistry, 2019-01) Selvaraj, Shyamsivappan; Raju, Vivek; Arjunan, Saravanan; Thangaraj, Arasakumar; Gopalan, Subashini; Thangaraj, Suresh; Ramasamy, Shankar; Palathurai, Subramaniam Mohan
    A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and benzylamine with (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for in vitro cytotoxic activity against the human cervical cancer cell line HeLa. The compounds have exhibited potent inhibition against human cervical cancer cells and insignificant toxicity to normal cells. The compounds 6d, 6a, 6h, 6b, and 6e induced apoptosis of HeLa cells, through ROS influx. The expression levels of proteins involved in the mitochondrion-related pathways were detected, and Western blot analysis showed that apoptosis occurred via activation of caspase-3.
  • No Thumbnail Available
    Item
    SYNTHESIS AND X-RAY STUDY OF DISPIRO 8-NITROQUINOLONE ANALOGUES AND THEIR CYTOTOXIC PROPERTIES AGAINST HUMAN CERVICAL CANCER HELA CELLS
    (Royal Society of Chemistry, 2019-01-22) Selvaraj, Shyamsivappan; Raju, Vivek; Arjunan, Saravanan; Thangaraj, Arasakumar; Gopalan, Subashini; Thangaraj, Suresh; Ramasamy, Shankar; Palathurai, Subramaniam Mohan
    A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and benzylamine with (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for in vitro cytotoxic activity against the human cervical cancer cell line HeLa. The compounds have exhibited potent inhibition against human cervical cancer cells and insignificant toxicity to normal cells. The compounds 6d, 6a, 6h, 6b, and 6e induced apoptosis of HeLa cells, through ROS influx. The expression levels of proteins involved in the mitochondrion-related pathways were detected, and Western blot analysis showed that apoptosis occurred via activation of caspase-3.
  • No Thumbnail Available
    Item
    SYNTHESIS AND X-RAY STUDY OF DISPIRO 8-NITROQUINOLONE ANALOGUES AND THEIR CYTOTOXIC PROPERTIES AGAINST HUMAN CERVICAL CANCER HELA CELLS
    (Med Chem Comm, 2019-01-22) Selvaraj, Shyamsivappan; Raju, Vivek; Arjunan, Saravanan; Thangaraj, Arasakumar; Gopalan, Subashini; Thangaraj, Suresh; Ramasamy, Shankar; Palathurai, Subramaniam Mohan
    A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and benzylamine with (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for in vitro cytotoxic activity against the human cervical cancer cell line HeLa. The compounds have exhibited potent inhibition against human cervical cancer cells and insignificant toxicity to normal cells. The compounds 6d, 6a, 6h, 6b, and 6e induced apoptosis of HeLa cells, through ROS influx. The expression levels of proteins involved in the mitochondrion-related pathways were detected, and Western blot analysis showed that apoptosis occurred via activation of caspase-3.
  • No Thumbnail Available
    Item
    A VERSATILE “ON-OFF-ON” QUINOLINE PYRAZOLINE HYBRID FOR SEQUENTIAL DETECTION OF CU2+ AND S− IONS TOWARDS BIO IMAGING AND TANNERY EFFLUENT MONITORING
    (Elsevier, 2018-11-01) Gopalan, Subashini; Arjunan, Saravanan; Selvaraj, Shyamsivappan; Thangaraj, Arasakumar; Viswanathan, Mahalingam; Ramasamy, Shankar; Palathurai, Subramaniam Mohan
    A quinoline-pyrazoline (QTP) module has been designed, synthesized and characterized as a fluorescence sensor for sequential detection of Cu2+ and S2− ions. The dual functional probe showed “on-off-on” property through displacement approach and because of fast kinetics between Cu2+ and S2− ion. Fluorescence imaging experiments with MG 63 cell lines exclusively demonstrate the applicability of Cu (II) imaging in biological systems. It is also used for the real-time analysis of sulphide ion in tannery effluent for environmental monitoring.