Browsing by Author "Sudha, D"

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    STRUCTURAL CHARACTERIZATION, DNA INTERACTION AND PHARMACOLOGICAL EVALUATION OF CU (II), CO (II), NI (II), FE (II) DIHYDRATE COMPLEXES DERIVED FROM PYRIDINE-2,5-DICARBOXYLIC ACID AND 2-METHYLIMIDAZOLE AS ORGANIC MOIETIES
    (Elsevier B.V, 2024) Sudha, D; Revathi, A; Arunadevi, N; Kirubavathy S, Jone
    The study of Metal organic coordination polymers is one of the most emerging areas of research in coordination chemistry because of their wide technological and interesting applications in pharmacology, sensor studies, catalysis, hydrogen storage devices, magnetic and NLO materials, ion exchange adsorption, metallic conductivity and luminescence studies. In this research work, microcrystalline transition metal [Cu (II), Co (II), Ni (II) and Fe (II)] complexes of Pyridine-2,5-dicarboxylic acid and 2-Methylimidazole as organic moieties were synthesized and analyzed for DNA interaction, biological properties like anti-cancer, anti-oxidant and anti-microbial activities. Structural characterization were studied using Fourier Transform-Infra Red spectroscopy (FT-IR), X-ray Diffractions (XRD), Ultraviolet-Visible spectroscopy (UV–VIS), Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-Ray analysis (EDX), Cyclic voltammetry (CV) and Thermo Gravimetric Analysis (TG-DTA). The copper complex demonstrates superior biological activity compared to alternative complexes, exhibiting antioxidant, antibacterial, and anticancer properties. From cytotoxicity results, it's evident that complexes (1–4) possess the capability to inhibit tumor cell growth while sparing normal cells, attributed to the metal atoms' strong affinity for cancer cells.
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    STRUCTURAL, OPTICAL, MORPHOLOGICAL AND ELECTROCHEMICAL PROPERTIES OF ZNO AND GRAPHENE OXIDE BLENDED ZNO NANOCOMPOSITES
    (Elsevier, 2023-03-01) Sudha, D; Ranjith Kumar, E; Shanjitha, S; Alaa M, Munshi; Gamil A.A, Al-Hazmi; Nashwa M, El-Metwaly; Jone Kirubavathy, S
    A simple cost-effective co-precipitation method was adopted to prepare ZnO nanoparticles from a metal organic framework. The synthesized ZnO nanoparticles were blended with graphene oxide (GO) to prepare the ZnO-GO nanocomposite. The physicochemical properties of ZnO nanoparticles and ZnO-GO nanocomposite were analyzed via various techniques. The structural behavior of ZnO and ZnO-GO nanocomposite was studied by XRD and FT-IR analysis. The XRD profile confirms the hexagonal structure with an average crystallite size of 19.4 nm for ZnO and 16.2 nm for ZnO-GO nanocomposites. The functional groups and the vibration modes of the samples were examined through FT-IR. It confirms the metallic presence in the ZnO and ZnO-GO samples in the wavenumber range of 400–600 cm−1. The optical properties of ZnO and ZnO-GO were studied via UV–vis spectra. The surface morphology of the samples was recorded through FESEM, and the elemental presence in the samples was examined by EDX. It confirms that the prepared samples are spherical in shape with uniform size distributions. Cyclic voltammetry has been used to study the redox behavior of electroactive ZnO and ZnO-GO composites.