Browsing by Author "Saranya, Thiruvenkataswamy"

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    CHITOSAN – AN ALTERNATIVE DRUG DELIVERY APPROACH FOR NEURODEGENERATIVE DISEASES
    (Elsevier Ltd, 2024) Mahalaxmi, Iyer; Ajay, Elangovan; Ramya, Sennimalai; Harysh Winster, Suresh Babu; Saranya, Thiruvenkataswamy; Jayalakshmi, Krishnan; Mukesh Kumar, Yadav; Abilash Valsala, Gopalakrishnan; Balachandar, Vellingiri
    Neurological disorders have become severe and dreadful issues around the globe that are rarely directly mediated because of the blood-brain barrier (BBB). Despite the various therapeutic strategies, including the utilization of cholinesterase inhibitors, metal chelators, molecular chaperones, and anti-body treatment that have been put forth, drug delivery to the brain has remained a problem in the treatment of neurodegenerative disorders (NDD). Chitosan, one of nature's multifunctional polymers, is acknowledged as a useful chemical in the medical and pharmaceutical industries due to its distinctive and flexible biological characteristics. By using Chitosan and its derivatives as drug delivery methods, it is possible to give medications in a sustained and regulated way, increase their stability, and lessen the likelihood of adverse drug reactions. In the current review, we have concentrated on the significance of Chitosan and its derivatives to become a hotspot in drug delivery, particularly for NDDs. This review also explains their properties as drug delivery vectors and their ability to cross the BBB, which is a significant obstacle to medication administration in NDDs. In conclusion, this review suggests that expanding the scope of such research would make it possible to develop NDD drug delivery systems that are more efficient.
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    PH DEPENDENT DRUG RELEASE OF SILIBININ, A POLYPHENOL CONJUGATED WITH MAGNETIC NANOPARTICLE AGAINST THE HUMAN COLON CANCER CELL
    (SpringerLink, 2020-04-03) Sennimalai, Ramya; Saranya, Thiruvenkataswamy; Krishnamoorthy, Kavithaa; Sivashanmugam, Preethi; Harysh, Winster; Vellingiri, Balachander; Manickam, Paulpandi; Arul, Narayanasamy
    Magnetic nanocarriers has become popularised in the research field as well as in the biomedical application due to their unique exotic possession, and processability. The present study involves the synthesis of nanocarrier, Iron Oxide nanoparticle conjugated with silibinin (SLN-Fe2O3) using co-precipitation method and also to detect their efficacy against the colon cancer cell. The synthesized SLN-Fe2O3 were undertaken for several analysis including UV-visible spectroscopy, dynamic light scattering, scanning electron microscope, Fourier transform infra-red spectroscopy, zeta potential analysis, and X-ray diffraction analysis. The analysis had end up in confirming the polydispersity and crystalline nature of the synthesized SLN-Fe2O3 with an average size of 70 nm. Further the synthesized SLN-Fe2O3 was undertaken for in vitro (AO/EtBR and DAPI) studies to find their effectiveness against human colon cancer using HT-29 cell line. The fragmentation occurs in nuclear material of the SLN-Fe2O3 treated cells had revealed that the cell death was due to the induction of apoptotic signals in the treated cancer cells. Thus the current study had clearly validated the potency of synthesized Iron Oxide nanoparticles conjugated with silibinin (SLN-Fe2O3) against the colon cancer cell and holds a promising therapeutic potency in treating cancer cells.