Browsing by Author "Parasuraman, Amutha"

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ANTIOXIDANT (IN VITRO), ANTIDIABETIC (IN VITRO) AND PHOTOCATALYTIC ACTIVITY OF COSTUS SPECIOSUS LEAF EXTRACT ASSISTED CS-AG-TIO2 COMPOSITES
(Springer Link, 2019-10-24) Chinnasamy, Surya; Nayagam, Agnel Arul John; Venkatesan, Pandiyan; Parasuraman, Amutha; Abílio José, Fraga do Nascimento Sobral; Balu, Krishnakumar
The researchers have currently targeted bio-synthesis nanoparticles (NPs) and their potential applications toward bio and photocatalytic field. The in vitro antidiabetic activity of noble metal modified TiO2 is really scare in literature. In the present work, green synthesis of CS-Ag nanoparticles was achieved through Costus speciosus (Crape ginger, an Indian ornamental plant, has long been medicinally used in traditional systems of medicine) leaf extract, and followed by solvothermal synthesis of CS-Ag-TiO2 composites. The prepared nanocomposites effectively utilized for in vitro antioxidant, in vitro antidiabetic study and azo dye AB 1 degradation under visible light.
BICL3-MODIFIED PERLITE AS AN EFFECTIVE CATALYST FOR SELECTIVE ORGANIC TRANSFORMATIONS: A GREEN PROTOCOL
(Springer Link, 2019-05-02) Kannan, Brindha; Parasuraman, Amutha; Balu, Krishnakumar; Abílio José, Fraga do Nascimento Sobral
A new perlite supported Bismuth Chloride (BiCl3) was used as an efficient heterogeneous catalyst for the synthesis of heterocyclic compounds viz., quinoxalines and dihydropyrimidinones. Fourier-transform infrared spectroscopy (FT–IR), scanning electron microscopy, energy dispersive spectra, X-ray diffractometry, thermogravimetric analysis and Brunauer–Emmett–Teller surface area analytical techniques were employed to characterize the prepared catalyst. Initially, the catalytic activity of the prepared BiCl3-Perlite was tested towards synthesis of simple quinoxaline derivatives at room temperature. The effect of solvent in the preparation of quinoxaline was also examined. The formed products were confirmed by their physical (melting point) and spectral data (FT–IR, 1H and 13C-NMR). In order to implement the activity of the BiCl3-Perlite catalyst, a multicomponent reaction was adopted for synthesis of dihydropyrimidinones under solvent free conditions in a micro oven. The use of recyclable heterogeneous solid acid catalyst makes the reaction simple with minimum chemical waste, shorter reaction time, easy workup and products in good yield.
SYNTHESIS, CHARACTERIZATION OF GELATIN ASSISTED ZNO AND ITS EFFECTIVE UTILIZATION OF TOXIC AZO DYE DEGRADATION UNDER DIRECT SUNLIGHT
(Elsevier, 2021-03) Balu, Krishnakumar; Ali, Alsalme; Fahad A, Alharthi; Durai, Mani; Anandan, K; Parasuraman, Amutha; Abilio J FN, Sobral
A highly solar active gelatin assisted ZnO (g/ZnO) was successfully synthesized by a sol-gel method. The photocatalyst was characterized by FE-SEM, HR-TEM, XRD, DRS, PL, FT-IR and Raman spectra. The prepared ZnO and g/ZnO were effectively utilized for toxic AB 1 azo dye degradation under direct sunlight. About 100% of degradation occurred with g/ZnO in a shorter time compared with prepared ZnO. The higher efficiency of g/ZnO in azo dye degradation under solar light may be due to higher visible light absorbance of g/ZnO compared with the prepared ZnO. A suitable degradation mechanism was proposed for AB 1 degradation under sunlight by g/ZnO. The g/ZnO was found to be sable and reusable. The addition of scavengers contributes a significant decrease in the photodegradation efficiency of the catalyst.
SYNTHESIS, CRYSTAL STRUCTURE, HIRSHFELD SURFACE, COMPUTATIONAL AND BIOLOGICAL STUDIES OF SPIRO-OXINDOLE DERIVATIVES AS MDM2-P53 INHIBITORS (Article)
(Springer Nature, 2024-08-29) Sivanandhan, Monisha; Ragupathy, Sutha; Thangamani, Arumugam; Parasuraman, Amutha
The spiro-oxindole derivatives were synthesized via a 1,3-dipolar cycloaddition approach and characterized by FT-IR, 1H, 13C NMR and mass spectral techniques. The single crystal XRD of 6d further validates the formation of compounds. DFT calculations indicated the reactive nature of compound 6d. Docking studies with 5LAW disclosed the minimum binding energy of − 10.83 kcal/mol for 6d. Furthermore, safe oral bioavailability was ensured by the physicochemical, pharmacokinetic, and toxicity predictions. The anticancer analysis of synthesized compounds showed substantial activity against A549 cells, notably with an IC50 value of 8.13 ± 0.66 µM for 6d compared to standard doxorubicin. 6d was also evaluated for cytotoxicity against L929 healthy cells and A549, showing selectivity towards A549 than healthy cells. AO/EB staining method showed early apoptotic cellular death in the A549 cell line in a dose-dependent manner.