Browsing by Author "Palanisamy, Senthilkumar"

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    CURCUMIN-LOADED NANOPARTICLES IN NEURODEGENERATIVE DISEASES: ALZHEIMER’S, PARKINSON’S, AND AMYOTROPHIC LATERAL SCLEROSIS (Book Chapter)
    (Springer Science and Business Media B.V., 2025-02-21) Palanisamy, Senthilkumar; Balasubramanian, Aiyar; Kanchana, Marimuthu; Sisubalan, Natarajan; Selvakesavan, Rajendran K
    Neurodegenerative diseases, including Alzheimer’s disease (AD)Alzheimer’s disease (AD), Parkinson’s disease (PD)Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal loss and have limited treatment options. CurcuminCurcumin, a bioactive compound derived from turmeric, exhibits multiple neuroprotective properties, making it a potential therapeuticTherapeutics agent for these conditions. However, its clinical use is restricted by poor bioavailability and rapid metabolism. CurcuminCurcumin has shown promise in treating neurodegenerative diseases like AD, PD, and ALS due to its anti-inflammatory, antioxidant, and neuroprotective properties. However, its clinical application is hampered by poor solubility in aqueous solutions, rapid metabolism, and limited bioavailability. These challenges have led researchers to explore innovative strategies to enhance curcuminCurcumin’s therapeutic potential. One promising approach is the use of nanoparticle-based delivery systems, which address these limitations by improving curcuminCurcumin’s stability and permeability across the blood-brain barrier (BBB)Blood-brain barrier (BBB) and providing controlled drug release. NanoparticlesNanoparticles (NPs) offer a viable solution to the challenges associated with curcuminCurcumin delivery. Their unique physicochemical properties, such as enhanced stability and targeted delivery capabilities, help overcome hurdles posed by curcuminCurcumin’s rapid metabolism and poor solubility. For instance, curcumin-loaded nanoparticles (CLNPs) have demonstrated improved drug bioavailability and better brainBrain penetration. Studies have shown that these nanoparticles enhance the therapeutic effects of curcuminCurcumin in neurodegenerative diseases by ensuring sustained release and targeted delivery, thereby addressing key limitations of curcuminCurcumin’s clinical use. Despite their potential benefits, several challenges remain in the application of CLNPs. Achieving consistent and efficient delivery across the BBBBlood-brain barrier (BBB) is a significant obstacle that must be addressed. Additionally, while CLNPs can enhance curcuminCurcumin’s bioavailability, the long-term safetySafety and efficacy of these formulations require further investigation. Potential concerns include immune responses, toxicityToxicity, and the scalability of manufacturing processes. Addressing these challenges through continued research and development will be crucial for the successful clinical translation of CLNPs, ensuring their safetySafety and effectiveness in treating neurodegenerative diseases. This chapter explores the innovative use of nanoparticle-based delivery systems to enhance the therapeutic potential of curcuminCurcumin in treating AD, PD, and ALS.
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    NANOPLASTICS IN HEAT-SENSITIVE FOOD PACKAGING: A REVIEW OF MIGRATION, DETECTION, HEALTH, AND ENVIRONMENTAL IMPACTS (Review)
    (Elsevier Ltd, 2025-03) Palanisamy, Senthilkumar; Saravana Kumar, Barani Kumar; Vetrivel, Aishwarya; Michael, Rahul Jacob; Babu, Nivethitha; Nallamuthu, Sanjay Sharan; Saravanan, Kokila; Venkatachalam, Shanmugam; Naveen Kumar, R J; Selvaraju, Gayathri Devi; Selvakesavan Rajendran, K; Lee, Jintae
    The widespread use of plastics in food packaging, particularly during heat processing, has raised significant concerns about the release of micro- and nanoplastics into food. This review comprehensively examines the sources, detection methods, health impacts, and environmental consequences of micro- and nanoplastics generated from heat-packed food. The mechanisms by which these particles are released during heating, sophisticated analytical methods for their detection, potential health risks from consumption, and the effects of these particles have on the environment are covered in detail. Current regulatory frameworks and mitigation strategies are critically assessed, highlighting challenges and opportunities in managing plastic contamination. Key research areas are identified to address knowledge gaps and improve food packaging safety. This review informs decision-making and policy development to mitigate the risks associated with micro- and nanoplastics in heat-packaged food.
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    PREPARATION OF CELLULOSE FIBER LOADED WITH CUO NANOPARTICLES FOR ENHANCED SHELF LIFE AND QUALITY OF TOMATO FRUIT (Article)
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024-06-10) Palanisamy, Senthilkumar; Varnan, Nandhana; Venkatachalam, Shanmugam; Kuppuswamy, Kumarakuru; Devi Selvaraju, Gayathri; Ranjith Santhosh Kumar, Devanesan Sanjeevi; Selvakesavan, Rajendran Kamalabai; Bangaru, Gokul; Bangaru, Gokul
    The present study reports on the preparation of a cellulose fiber (CF) composite from D. lutescens, combined with copper oxide nanoparticles (DL@CF/CuO), to prolong the shelf life of tomatoes after harvest. The isolated cellulose fiber material was comprehensively characterized using XRD, FTIR, and FE-SEM analyses. The DLCF and DL@CF/CuO nanoparticles exhibited crystalline cellulose, as indicated by the XRD investigation. Both DLCF and DL@CF/CuO showed O-H and C-H FTIR spectra with identifiable vibrational peaks. The FE-SEM images depicted the dispersion of DL@CF/CuO-based fibers in a cellulose fiber matrix containing CuO nanoparticles. A 0.3% (wt/wt), a solution of DL@CF/CuO was coated onto the surface of early ripening tomato fruits. After a 25-day storage period at 25–29 °C and 85% RH, the results showed a significant extension in the shelf life of the tomato fruits, in line with changes in physiological properties and fruit quality. The extension of shelf life in tomato fruit epidermis treated with DL@CF/CuO was confirmed through FE-SEM analysis. L929 fibroblast cells were treated with the developed DL@CF/CuO nanocomposite, and no signs of toxicity were detected up to 75 µg/mL. Additionally, the DL@CF/CuO nanocomposite exhibited significant antifungal activity against Aspergillus flavus. In conclusion, this study provides novel insights for sustainable food security and waste control in the agricultural and food industries.