Browsing by Author "Mathiyazhagan, Narayanan"

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ANTIOXIDANT AND ANTICANCER POTENTIAL OF ETHYL ACETATE EXTRACT OF BARK AND FLOWER OF TECOMA STANS (LINN) AND IN SILICO STUDIES ON PHYTOLIGANDS AGAINST BCL 2 AND VEGFR2 FACTORS
(Elsevier, 2023-02-15) Mathiyazhagan, Narayanan; Anburaj, Gothandapani; Rajasudha, Venugopalan; Manikandan, Rethinam; Sakunthala, Pitchai; Tahani, Awad Alahmadi; Hesham S, Almoallim; Sabariswaran, Kandasamy; Kathirvel, Brindhadevi
This study was designed to appraise the antioxidant and anticancer competence of solvent extracts of Tecoma stans (Linn) and analyze the phytoligands interaction against Bcl 2 VEGFR2 through in silico studies. The phytochemical analysis revealed that the ethyl acetate extract contains more number of pharmaceutically valuable phytochemicals than other solvent extracts. Among the various phytochemicals, flavonoid was found as a predominant component, and UV–Vis- spectrophotometer analysis initially confirmed it. Hence, the column chromatogram was performed to purify the flavonoid, and High-performance liquid chromatography (HPLC) was performed. It revealed that the flavonoid enriched fraction by compared with standard flavonoid molecules. About 84.69% and 80.43% of antioxidant activity were found from ethyl acetate extract of bark and flower at the dosage of 80 μg mL−1 with the IC50 value of 47.24 and 43.40 μg mL−1, respectively. In a dose-dependent mode, the ethyl acetate extract of bark and flower showed cytotoxicity against breast cancer cell line MCF 7 (Michigan Cancer Foundation-7) as up to 81.38% and 80.94% of cytotoxicity respectively. Furthermore, the IC50 was found as 208.507 μg mL−1 and 207.38 μg mL−1 for bark and flower extract correspondingly. About 10 medicinal valued flavonoid components were identified from bark (6) and flower (4) ethyl acetate extract through LC-MS analysis. Out of 10 components, the 3,5-O-dicaffeoylquinic acid (ΔG -8.8) and Isorhamnetin-3-O-rutinoside (ΔG -8.3) had the competence to interact with Bcl 2 (B-Cell Lymphoma 2) and VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) respectively with more energy. Hence, these results confirm that the ethyl acetate extract of bark and flower of T. stans has significant medicinal potential and could be used as antioxidant and anticancer agent after some animal performance study.
ASSESSING POLLUTANT SORPTION EFFICIENCY OF MODIFIED AND UNMODIFIED BIOCHAR WITH BACILLUS CEREUS ON CONTAMINATED LAKE WATER: IMPLICATIONS FOR ORYZA SATIVA SEEDLING AND ARTEMIA FRANCISCANA LARVAE VIABILITY
(Springer Link, 2023-10-02) Mathiyazhagan, Narayanan; Ramesh, Subramani; Sabariswaran, Kandasamy
This study evaluated the efficacy of biochar in removing pollutants from a polluted lake. Biochar, both with and without Bacillus cereus, was assessed for its sorption potential. The treated water samples were analyzed for toxicity using Oryza sativa and Artemia franciscana larvae. The lake water exceeded permissible limits for pH, turbidity, dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD), and various metals. The 10-day biosorption study with different treatment groups (MB, UMB, MBB, UMBB, and BC) revealed that the MBB group exhibited remarkable pollutant sorption potential. It achieved pollutant removal percentages of 33.35% for Cd, 15.73% for As, 26.21% for Cr, 32.72% for Pb, 32.81% for Zn, 23.58% for Cu, 5.44% for Cl, 22.01% for Ni, 28.2% for Hg, and 4.19% for SO42−. MBB-treated lake water showed no toxicity, confirming pollutant removal by metal-tolerant Bacillus cereus in modified biochar.
ASSESSING POLLUTANT SORPTION EFFICIENCY OF MODIFIED AND UNMODIFIED BIOCHAR WITH BACILLUS CEREUS ON CONTAMINATED LAKE WATER: IMPLICATIONS FOR ORYZA SATIVA SEEDLING AND ARTEMIA FRANCISCANA LARVAE VIABILITY
(Springer Link, 2023-10-02) Mathiyazhagan, Narayanan; Ramesh, Subramani; Sabariswaran, Kandasamy
This study evaluated the efficacy of biochar in removing pollutants from a polluted lake. Biochar, both with and without Bacillus cereus, was assessed for its sorption potential. The treated water samples were analyzed for toxicity using Oryza sativa and Artemia franciscana larvae. The lake water exceeded permissible limits for pH, turbidity, dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD), and various metals. The 10-day biosorption study with different treatment groups (MB, UMB, MBB, UMBB, and BC) revealed that the MBB group exhibited remarkable pollutant sorption potential. It achieved pollutant removal percentages of 33.35% for Cd, 15.73% for As, 26.21% for Cr, 32.72% for Pb, 32.81% for Zn, 23.58% for Cu, 5.44% for Cl, 22.01% for Ni, 28.2% for Hg, and 4.19% for SO42−. MBB-treated lake water showed no toxicity, confirming pollutant removal by metal-tolerant Bacillus cereus in modified biochar.
ASSESSING POLLUTANT SORPTION EFFICIENCY OF MODIFIED AND UNMODIFIED BIOCHAR WITH BACILLUS CEREUS ON CONTAMINATED LAKE WATER: IMPLICATIONS FOR ORYZA SATIVA SEEDLING AND ARTEMIA FRANCISCANA LARVAE VIABILITY
(Springer Link, 2023-10-02) Mathiyazhagan, Narayanan; Ramesh, Subramani; Sabariswaran, Kandasamy
This study evaluated the efficacy of biochar in removing pollutants from a polluted lake. Biochar, both with and without Bacillus cereus, was assessed for its sorption potential. The treated water samples were analyzed for toxicity using Oryza sativa and Artemia franciscana larvae. The lake water exceeded permissible limits for pH, turbidity, dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD), and various metals. The 10-day biosorption study with different treatment groups (MB, UMB, MBB, UMBB, and BC) revealed that the MBB group exhibited remarkable pollutant sorption potential. It achieved pollutant removal percentages of 33.35% for Cd, 15.73% for As, 26.21% for Cr, 32.72% for Pb, 32.81% for Zn, 23.58% for Cu, 5.44% for Cl, 22.01% for Ni, 28.2% for Hg, and 4.19% for SO42−. MBB-treated lake water showed no toxicity, confirming pollutant removal by metal-tolerant Bacillus cereus in modified biochar.
ASSESSING THE ECOLOGICAL IMPACT OF PESTICIDES/HERBICIDES ON ALGAL COMMUNITIES: A COMPREHENSIVE REVIEW
(Elsevier B.V, 2024-03) Mathiyazhagan, Narayanan; Kesavan, Devarayan; Monu, Verma; Manickam, Selvaraj; Hamed A, Ghramh; Sabariswaran, Kandasamy
The escalating use of pesticides in agriculture for enhanced crop productivity threatens aquatic ecosystems, jeopardizing environmental integrity and human well-being. Pesticides infiltrate water bodies through runoff, chemical spills, and leachate, adversely affecting algae, vital primary producers in marine ecosystems. The repercussions cascade through higher trophic levels, underscoring the need for a comprehensive understanding of the interplay between pesticides, algae, and the broader ecosystem. Algae, susceptible to pesticides via spillage, runoff, and drift, experience disruptions in community structure and function, with certain species metabolizing and bioaccumulating these contaminants. The toxicological mechanisms vary based on the specific pesticide and algal species involved, particularly evident in herbicides' interference with photosynthetic activity in algae. Despite advancements, gaps persist in comprehending the precise toxic effects and mechanisms affecting algae and non-target species. This review consolidates information on the exposure and toxicity of diverse pesticides and herbicides to aquatic algae, elucidating underlying mechanisms. An emphasis is placed on the complex interactions between pesticides/herbicides, nutrient content, and their toxic effects on algae and microbial species. The variability in the harmful impact of a single pesticide across different algae species underscores the necessity for further research. A holistic approach considering these interactions is imperative to enhance predictions of pesticide effects in marine ecosystems. Continued research in this realm is crucial for a nuanced understanding of the repercussions of pesticides and herbicides on aquatic ecosystems, mainly algae.
ASSESSING THE ECOLOGICAL IMPACT OF PESTICIDES/HERBICIDES ON ALGAL COMMUNITIES: A COMPREHENSIVE REVIEW (Review)
(Elsevier, 2024-03) Mathiyazhagan, Narayanan; Kesavan, Devarayan; Monu, Verma; Manickam, Selvaraj; Hamed A, Ghramh; Sabariswaran, Kandasamy
The escalating use of pesticides in agriculture for enhanced crop productivity threatens aquatic ecosystems, jeopardizing environmental integrity and human well-being. Pesticides infiltrate water bodies through runoff, chemical spills, and leachate, adversely affecting algae, vital primary producers in marine ecosystems. The repercussions cascade through higher trophic levels, underscoring the need for a comprehensive understanding of the interplay between pesticides, algae, and the broader ecosystem. Algae, susceptible to pesticides via spillage, runoff, and drift, experience disruptions in community structure and function, with certain species metabolizing and bioaccumulating these contaminants. The toxicological mechanisms vary based on the specific pesticide and algal species involved, particularly evident in herbicides' interference with photosynthetic activity in algae. Despite advancements, gaps persist in comprehending the precise toxic effects and mechanisms affecting algae and non-target species. This review consolidates information on the exposure and toxicity of diverse pesticides and herbicides to aquatic algae, elucidating underlying mechanisms. An emphasis is placed on the complex interactions between pesticides/herbicides, nutrient content, and their toxic effects on algae and microbial species. The variability in the harmful impact of a single pesticide across different algae species underscores the necessity for further research. A holistic approach considering these interactions is imperative to enhance predictions of pesticide effects in marine ecosystems. Continued research in this realm is crucial for a nuanced understanding of the repercussions of pesticides and herbicides on aquatic ecosystems, mainly algae.
THE BIOTRANSFORMATION POTENTIAL OF BACILLUS CEREUS ON Β- CYPERMETHRIN TO PROTECT THE EARTHWORM (PERIONYX EXCAVATUS) ON INSECTICIDE -CONTAMINATED SOIL
(Taylor & Francis Online, 2022) Mathiyazhagan, Narayanan; Jimmandiyur, Mathappan Murugan; Gajendiran, Kandasamy; Sabariswaran, Kandasamy; Manikandan, Rajendran
The pre-isolated B. cereus had shown better β-cypermethrin resistance at 100 mg L−1 dosage in the Mineral Salt Medium (MSM). Hence, it was applied for the biodegradation study on MSM. The GC-MS analysis revealed that the B. cereus had the potential to degrade β-cypermethrin and metabolize it into six predominant less or nontoxic components (benzene, 1-ethyl−3-methyl-, ethanethiol, 2-(dimethylamino)-, 1-(2-acetoxyethyl)-3,6-diazahomoadamantan-9-one, silane, 9-anthracenyltrimethyl-, 1-(3-hydroxy-3-methylbutyl)-3,6-,fumaric acid). Based on this biodegradation potential, four experimental groups, namely A, B, C, D and control, were framed and the biodegradation potential of B. cereus on β-cypermethrin and interaction with P. excavates were studied. Group C, which includes B. cereus and 10 P. excavates under β-cypermethrin stress excavates positive survival interaction. It was confirmed by the presence of metabolites such as benzene, 1-ethyl-3-methyl-, ethanethiol, 2-(dimethylamino)- and 1-(2-acetoxyethyl)-3,6-diazahomoadamantan-9-one, in P. excavates. Furthermore, these were similar to the metabolites of β-cypermethrin degraded by B. cereus. These results conclude that the biodegradation potential of B. cereus can protect the life of P. excavates from β-cypermethrin toxicity and thus, can support the balancing of soil fertility, structure and soil biotas such as flora and fauna.
THE CURRENT STATE OF ALGAE IN WASTEWATER TREATMENT AND ENERGY CONVERSION: A CRITICAL REVIEW
(Elsevier, 2023-06) Sabariswaran, Kandasamy; Mathiyazhagan, Narayanan; Rathinam, Raja; Kesavan, Devarayan; R, Kavitha
Due to the rapid expansion of the global economy and population, there aren't enough water resources accessible for direct human consumption. Therefore, water remediation will unavoidably take center stage on a worldwide platform. The development of microalgae can be supported by several types of wastewater (WW). They might be able to clean up pollutants from industry and urban effluents. Due to its low energy requirements, microalgae's capacity to survive in various environmental circumstances, and the potential to convert WW nutrients into high-value chemicals, microalgae-based wastewater treatment (WWT) has already received attention. Recent studies have reported using microalgae to remove pharmaceutical compounds and pesticides from wastewater produced by industrial and agricultural processes and removing nutrients from wastewater from WWTs. As a result, utilizing microalgae for both wastewater treatment and biofuel production could be a cost-effective solution to these challenges. This review emphasizes recent developments in the production of microalgae for WW cleanup. Additionally, it highlights the current problems and opportunities in the emerging algae-based sector.
THE CURRENT STATE OF ALGAE IN WASTEWATER TREATMENT AND ENERGY CONVERSION: A CRITICAL REVIEW
(Elsevier, 2023-06) Sabariswaran, Kandasamy; Mathiyazhagan, Narayanan; Rathinam, Raja; Kesavan, Devarayan; Kavitha, R
Due to the rapid expansion of the global economy and population, there aren't enough water resources accessible for direct human consumption. Therefore, water remediation will unavoidably take center stage on a worldwide platform. The development of microalgae can be supported by several types of wastewater (WW). They might be able to clean up pollutants from industry and urban effluents. Due to its low energy requirements, microalgae's capacity to survive in various environmental circumstances, and the potential to convert WW nutrients into high-value chemicals, microalgae-based wastewater treatment (WWT) has already received attention. Recent studies have reported using microalgae to remove pharmaceutical compounds and pesticides from wastewater produced by industrial and agricultural processes and removing nutrients from wastewater from WWTs. As a result, utilizing microalgae for both wastewater treatment and biofuel production could be a cost-effective solution to these challenges. This review emphasizes recent developments in the production of microalgae for WW cleanup. Additionally, it highlights the current problems and opportunities in the emerging algae-based sector.
CURRENT STATUS OF MICROBES INVOLVED IN THE DEGRADATION OF PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) POLLUTANTS IN THE AQUATIC ECOSYSTEM
(Elsevier, 2022-05-01) Mathiyazhagan, Narayanan; Mostafa, El-sheekh; Ying, Ma; Arivalagan, Pugazhendhi; Devarajan, Natarajan; Gajendiran, Kandasamy; Rathinam, Raja; Saravana Kumar, R.M; Suresh, Kumarasamy; Govindasamy, Sathiyan; Geetha, R; Balaji, Paulraj; Guanglong, Liu; Sabariswaran, Kandasamy
Contamination of aquatic systems with pharmaceuticals, personal care products, steroid hormones, and agrochemicals has been an immense problem for the earth's ecosystem and health impacts. The environmental issues of well-known persistence pollutants, their metabolites, and other micro-pollutants in diverse aquatic systems around the world were collated and exposed in this review assessment. Waste Water Treatment Plant (WWTP) influents and effluents, as well as industrial, hospital, and residential effluents, include detectable concentrations of known and undiscovered persistence pollutants and metabolites. These components have been found in surface water, groundwater, drinking water, and natural water reservoirs receiving treated and untreated effluents. Several studies have found that these persistence pollutants, and also similar recalcitrant pollutants, are hazardous to a variety of non-targeted creatures in the environment. In human and animals, they can also have severe and persistent harmful consequences. Because these pollutants are harmful to aquatic organisms, microbial degradation of these persistence pollutants had the least efficiency. Fortunately, only a few wild and Genetically Modified (GMOs) microbial species have the ability to degrade these PPCPs contaminants. Hence, researchers have been studying the degradation competence of microbial communities in persistence pollutants of Pharmaceutical and Personal Care Products (PPCPs) and respective metabolites for decades, as well as possible degradation processes in various aquatic systems. As a result, this review provides comprehensive information about environmental issues and the degradation of PPCPs and their metabolites, as well as other micro-pollutants, in aquatic systems.
INFLUENCES OF WILDFIRE ON THE FOREST ECOSYSTEM AND CLIMATE CHANGE: A COMPREHENSIVE STUDY
(Elsevier Inc, 2024-01) Kandasamy, Gajendiran; Sabariswaran, Kandasamy; Mathiyazhagan, Narayanan
Wildfires have complex impacts on forests, including changes in vegetation, threats to biodiversity, and emissions of greenhouse gases like carbon dioxide, which exacerbate climate change. The influence of wildfires on animal habitats is particularly noteworthy, as they can lead to significant changes in native environments. The extent of these alterations in species and habitats plays a crucial role in shaping forest ecology. Drought, disease, insect infestations, overgrazing, or their combined effects can amplify the negative effects on specific plant genera and entire ecosystems. In addition to the immediate consequences of plant mortality and altered community dynamics, forest fires have far-reaching implications. They often increase flowering and seed production, further influencing ecological communities. However, one concerning trend is the decline in the diversity of forest biological species within fire-affected areas. Beyond their ecological impacts, wildfires emit substantial quantities of greenhouse gases and fine particulates into the atmosphere, triggering profound changes in climate patterns and contributing to global warming. As vegetation burns during these fires, the carbon stored within is released, rendering large forest fires detrimental to biodiversity and the emission of CO2, a significant contributor to global warming. Measuring the global impact of wildfires on ecological communities and greenhouse gas emissions has become increasingly vital. These research endeavors shed light on the intricate relationships and feedback loops linking wildfires, ecosystem inhabitants, and the evolving climate landscape.
INFLUENCES OF WILDFIRE ON THE FOREST ECOSYSTEM AND CLIMATE CHANGE: A COMPREHENSIVE STUDY (Review)
(Elsevier, 2024-01-01) Kandasamy, Gajendiran; Sabariswaran, Kandasamy; Mathiyazhagan, Narayanan
Wildfires have complex impacts on forests, including changes in vegetation, threats to biodiversity, and emissions of greenhouse gases like carbon dioxide, which exacerbate climate change. The influence of wildfires on animal habitats is particularly noteworthy, as they can lead to significant changes in native environments. The extent of these alterations in species and habitats plays a crucial role in shaping forest ecology. Drought, disease, insect infestations, overgrazing, or their combined effects can amplify the negative effects on specific plant genera and entire ecosystems. In addition to the immediate consequences of plant mortality and altered community dynamics, forest fires have far-reaching implications. They often increase flowering and seed production, further influencing ecological communities. However, one concerning trend is the decline in the diversity of forest biological species within fire-affected areas. Beyond their ecological impacts, wildfires emit substantial quantities of greenhouse gases and fine particulates into the atmosphere, triggering profound changes in climate patterns and contributing to global warming. As vegetation burns during these fires, the carbon stored within is released, rendering large forest fires detrimental to biodiversity and the emission of CO2, a significant contributor to global warming. Measuring the global impact of wildfires on ecological communities and greenhouse gas emissions has become increasingly vital. These research endeavors shed light on the intricate relationships and feedback loops linking wildfires, ecosystem inhabitants, and the evolving climate landscape.
MARINE BIORESOURCES ARE A BOON FOR BIOPLASTIC PRODUCTION AS AN ALTERNATIVE TO CONVENTIONAL PLASTICS—A REVIEW
(SpringerLink, 2023-08-30) Mathiyazhagan, Narayanan; Jintae, Lee; Selvaraj, Barathi; Sabariswaran, Kandasamy
The constant rise in global demand for plastic products has led to an uninterrupted increase in the production and utilization of petroleum-based conventional plastics. This has resulted in significant contamination of plastic waste due to its non-biodegradable nature, particularly within aquatic ecosystems, while the availability of petroleum resources is decreasing. Additionally, although bioplastics have been introduced as alternatives to traditional plastics, their primary production from plant sources has raised concerns regarding their harmful effects on ecosystems and human well-being. In response to these challenges, marine-based bioplastics have emerged as a promising and economically feasible solution to meet the growing demand for plastic products. Marine bioresource–based bioplastics possess favorable physicochemical properties and exhibit ease of degradation, making them attractive compounds for various applications. However, implementing marine bioplastics on a large scale requires further investigation. Therefore, the main objectives of this review are to emphasize the existing scientific gaps within the specific research area and clearly state the review’s objective view. Hence, this review provides a comprehensive summary of micro and microorganisms derived from marine resources for bioplastic production and explores potential applications in promoting human welfare without causing harm to the ecosystem.
MARINE BIORESOURCES ARE A BOON FOR BIOPLASTIC PRODUCTION AS AN ALTERNATIVE TO CONVENTIONAL PLASTICS—A REVIEW
(Springer Link, 2023-08-30) Mathiyazhagan, Narayanan; Jintae, Lee; Selvaraj, Barathi; Sabariswaran, Kandasamy
The constant rise in global demand for plastic products has led to an uninterrupted increase in the production and utilization of petroleum-based conventional plastics. This has resulted in significant contamination of plastic waste due to its non-biodegradable nature, particularly within aquatic ecosystems, while the availability of petroleum resources is decreasing. Additionally, although bioplastics have been introduced as alternatives to traditional plastics, their primary production from plant sources has raised concerns regarding their harmful effects on ecosystems and human well-being. In response to these challenges, marine-based bioplastics have emerged as a promising and economically feasible solution to meet the growing demand for plastic products. Marine bioresource–based bioplastics possess favorable physicochemical properties and exhibit ease of degradation, making them attractive compounds for various applications. However, implementing marine bioplastics on a large scale requires further investigation. Therefore, the main objectives of this review are to emphasize the existing scientific gaps within the specific research area and clearly state the review’s objective view. Hence, this review provides a comprehensive summary of micro and microorganisms derived from marine resources for bioplastic production and explores potential applications in promoting human welfare without causing harm to the ecosystem.
MICROALGAE AS A MULTIPOTENTIAL ROLE IN COMMERCIAL APPLICATIONS: CURRENT SCENARIO AND FUTURE PERSPECTIVES
(Elsevier, 2022-01-15) Sabariswaran, Kandasamy; Bo, Zhang; Zhixia, He; Narayanamoorthy, Bhuvanendran; Ahmed I., EL-Seesy; Qian, Wang; Mathiyazhagan, Narayanan; Palaniswamy, Thangavel; Mudasir A., Dar
Microalgal feedstocks have gained tremendous potential for sustainable biofuel production in recent years. For biofuel processing, thermochemical, biochemical, and transesterification processes are used. Many researchers have recently become interested in the hydrothermal liquefaction of microalgae. Renewable biofuel production from microalgae, as well as a broad range of value-added co-products, describe its potential as a biorefinery feedstock from this perspective. Microalgae convert solar energy into carbon storage compounds, such as TAG (triacylglycerols), which can then be converted into biodiesel, bioethanol, and bio-methanol. Microalgae are considered to be the most attractive source of biofuel production for all the organisms used. This review explored the percentage of oil content, chemical composition, and lipid content of microalgae. This analysis depicts the various aspects of microalgal species for biofuel conversion. Also, other bioenergy and value-added items are discussed briefly.
MICROBIAL DEGRADATION AND TRANSFORMATION OF PPCPS IN AQUATIC ENVIRONMENT: A REVIEW
(Pub Med, 2023-08) Mathiyazhagan, Narayanan; Sabariswaran, Kandasamy; Jintae, Lee; Selvaraj, Barathi
The Pharmaceuticals and Personal Care Products (PPCPs) presence at harmful levels has been identified in aquatic ecosystems all over the world. Currently, PPCPs are more common in aquatic regions and have been discovered to be extremely harmful to aquatic creatures. Waste-water treatment facilities are the primary cause of PPCPs pollution in aquatic systems due to their limited treatment as well as the following the release of PPCPs. The degree of PPCPs elimination is primarily determined by the method applied for the remediation. It must be addressed in an eco-friendly manner in order to significantly improve the environmental quality or, at the very least, to prevent the spread as well as effects of toxic pollutants. However, when compared to other methods, environmentally friendly strategies (biological methods) are less expensive and require less energy. Most biological methods under aerobic conditions have been shown to degrade PPCPs effectively. Furthermore, the scientific literature indicates that with the exception of a few extremely hydrophobic substances, biological degradation by microbes is the primary process for the majority of PPCPs compounds. Hence, this review discusses about the optimistic role of microbe concerned in the degradation or transformation of PPCPs into non/less toxic form in the polluted environment. Accordingly, more number of microbial strains has been implicated in the biodegradation/transformation of harmful PPCPs through a process termed as bioremediation and their limitations.
MICROBIAL DEGRADATION AND TRANSFORMATION OF PPCPS IN AQUATIC ENVIRONMENT: A REVIEW
(Elsevier Ltd, 2023-08) Mathiyazhagan, Narayanan; Sabariswaran, Kandasamy; Jintae, Lee; Selvaraj, Barathi
The Pharmaceuticals and Personal Care Products (PPCPs) presence at harmful levels has been identified in aquatic ecosystems all over the world. Currently, PPCPs are more common in aquatic regions and have been discovered to be extremely harmful to aquatic creatures. Waste-water treatment facilities are the primary cause of PPCPs pollution in aquatic systems due to their limited treatment as well as the following the release of PPCPs. The degree of PPCPs elimination is primarily determined by the method applied for the remediation. It must be addressed in an eco-friendly manner in order to significantly improve the environmental quality or, at the very least, to prevent the spread as well as effects of toxic pollutants. However, when compared to other methods, environmentally friendly strategies (biological methods) are less expensive and require less energy. Most biological methods under aerobic conditions have been shown to degrade PPCPs effectively. Furthermore, the scientific literature indicates that with the exception of a few extremely hydrophobic substances, biological degradation by microbes is the primary process for the majority of PPCPs compounds. Hence, this review discusses about the optimistic role of microbe concerned in the degradation or transformation of PPCPs into non/less toxic form in the polluted environment. Accordingly, more number of microbial strains has been implicated in the biodegradation/transformation of harmful PPCPs through a process termed as bioremediation and their limitations.
MICROBIAL DEGRADATION AND TRANSFORMATION OF PPCPS IN AQUATIC ENVIRONMENT: A REVIEW
(Elsevier Ltd, 2023-07) Mathiyazhagan, Narayanan; Sabariswaran, Kandasamy; Jintae, Lee; Selvaraj, Barathi
The Pharmaceuticals and Personal Care Products (PPCPs) presence at harmful levels has been identified in aquatic ecosystems all over the world. Currently, PPCPs are more common in aquatic regions and have been discovered to be extremely harmful to aquatic creatures. Waste-water treatment facilities are the primary cause of PPCPs pollution in aquatic systems due to their limited treatment as well as the following the release of PPCPs. The degree of PPCPs elimination is primarily determined by the method applied for the remediation. It must be addressed in an eco-friendly manner in order to significantly improve the environmental quality or, at the very least, to prevent the spread as well as effects of toxic pollutants. However, when compared to other methods, environmentally friendly strategies (biological methods) are less expensive and require less energy. Most biological methods under aerobic conditions have been shown to degrade PPCPs effectively. Furthermore, the scientific literature indicates that with the exception of a few extremely hydrophobic substances, biological degradation by microbes is the primary process for the majority of PPCPs compounds. Hence, this review discusses about the optimistic role of microbe concerned in the degradation or transformation of PPCPs into non/less toxic form in the polluted environment. Accordingly, more number of microbial strains has been implicated in the biodegradation/transformation of harmful PPCPs through a process termed as bioremediation and their limitations.
THE PHARMACEUTICAL POTENTIAL OF CRUDE ETHANOL LEAF EXTRACT OF PEDALIUM MUREX (L.)
(Elsevier, 2022) Mathiyazhagan, Narayanan; Arunachalam, Kiran; Devarajan, Natarajan; Sabariswaran, Kandasamy; Sabarathinam, Shanmugam; Maha, Alshiekheid; Hesham S, Almoallim; Arivalagan, Pugazhendhi
The purpose of this study was to determine the antibacterial competence of various solvent leaf extracts of Pedalium murex against bacteria that cause skin infections such as Staphylococcus aureus, (folliculitis), Streptococcus pyogenes (impetigo), and Corynebacterium sp. (pitted keratolysis). The presence of phytochemicals, antioxidant activity, and cytotoxicity on the Human Embryonic Kidney (HEK 293) cell line were also studied. The ethanol extract contained more phytochemical ingredients (saponins, flavonoids, alkaloids, terpenoids, phenolics, quinones, and betacyanin) than the other extracts. An increased concentration of ethanol extract demonstrated excellent antibacterial activity (zone of inhibition) against bacteria such as S. aureus, S. pyogenes, and Corynebacterium sp. and it followed by methanol extract. This is the first report on the antibacterial activity of an ethanol extract of P. murex against bacteria that cause skin infections. The average minimum inhibitory concentration (MIC) value of ethanol extract was found as 13.64 mg mL−1. In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl free radical scavenging assay, the crude ethanol (87.25 and 83.24 % respectively) and methanol extracts (81.41% and 78.39% respectively) showed excellent antioxidant activity. The cytotoxicity study (4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) revealed that the crude ethanol extract of P. murex effectively supported the proliferation of HEK 293 cell line with the absence of considerable number of cell death even at 500 mg mL−1. The findings concluded that the components present in the ethanol extract could be used in drug formulations to combat bacteria that cause skin infections without causing side effects.
PHYTOCHEMICAL PROFILE AND LARVICIDAL ACTIVITY OF AQUEOUS EXTRACT OF OCIMUM AMERICANUM AGAINST MOSQUITO VECTORS
(SpringerLink, 2023) Mathiyazhagan, Narayanan; Vijay A; Sabariswaran, Kandasamy; Omaima, Nasif; Sulaiman Ali, Alharbi; Ramalingam, Srinivasan; Kavitha R
The primary goal of this research was to evaluate the phytochemicals, including bioactive components of Ocimum americanum extracts and assess their larvicidal potential against 3rd and 4th instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus. The aqueous extraction process on O. americanum provides higher yield (9.61 ± 0.11%) and a significant volume of phytochemicals (tannins, saponins, terpenoids, flavonoids, alkaloids, protein, and carbohydrate) than other solvents (methanol, ethanol, acetone, petroleum ether, and chloroform) extracts. Fourier-transform infrared spectroscopy and high-performance liquid chromatography analyses revealed about eight predominant phytochemicals/functional groups in O. americanum aqueous extract. Surprisingly, in gas chromatography–mass spectrometry analysis, about 30 bioactive components were found in the aqueous extract of O. americanum, the majority of which had previously been identified as medicinally valuable bioactive components. Furthermore, these bioactive components containing aqueous extract demonstrated significant larvicidal activity against 3rd and 4th instar larvae of A. aegypti, An. stephensi, and C. quinquefasciatus after 24 h of treatment at concentrations ranging from 35 to 50 mg mL−1. Thus, their outstanding larvicidal potential on 3rd and 4th instar larvae, the phytochemicals present in the aqueous extract of O. americanum could be used to control mosquito duplication and vector-borne diseases.