Browsing by Author "Kavitha R"

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    ANTIMICROBIAL, ANTIOXIDANT, ANTICANCER, AND ANTITHROMBOTIC, COMPETENCY OF SAPONINS FROM THE ROOT OF DECALEPIS HAMILTONII
    (Elsevier, 2023-08-15) Jayaraman, Gitanjali; Duraisamy, Sumathi Dinesh Ram; Kavitha R; Venkatesan, Amalan; Tahani, Awad Alahmadi; Sulaiman Ali, Alharbi; Sabariswaran, Kandasamy; Rajasree, Shanmuganthan; Natesan, Vijayakumar
    The goal of this study was to extract saponins from the tuberous root of Decalepis hamiltonii and assess their potential clinical applications, which included antioxidant, antibacterial, antithrombotic, and anticancer properties. Surprisingly, the results of this study revealed that the extracted saponins have excellent antioxidant activities, as demonstrated by 2,2-diphenylpicrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Hydrogen peroxide (H2O2), and Nitric oxide (NO) scavenging assays. Nonetheless, at a concentration of 100 g/mL, crude saponin had excellent antibacterial activity, particularly against gramme positive bacteria (Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis, and Micrococcus luteus), followed by gramme negative bacteria (Escherichia coli, Salmonella typhi, Proteus mirabilis, and Klebsiella pneumonia). Despite this, the crude saponin had no effect on Aspergillus niger and Candida albicans. The crude saponin also possesses outstanding in vitro antithrombotic activity on blood clot. Interestingly, the crude saponins have an outstanding anticancer activity of 89.26%, with an IC50 value of 58.41 μg/mL. Overall, the findings conclude that crude saponin derived from D. hamiltonii tuberous root could be used in pharmaceutical formulations.
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    EFFECT OF HALL CURRENT ON HEAT AND MASS TRANSFER OF FREE CONVECTIVE FLOW OVER A FLAT POROUS PLATE EMBEDDED IN POROUS MEDIUM – A NUMERICAL INVESTIGATION
    (Nonlinear Analysis and Differential Equations, 2016) Sumathi K; Arunachalam T; Kavitha R
    An analysis of the effect of Hall current on free convective MHD flow along with heat and mass transfer over a flat porous plate embedded in porous mediumhas been carried outnumerically. The governing non-linear partial differentialequations together with the boundary conditions are reduced to a system of non-linear ordinary differential equations by using similarity transformations. The system of non-linear ordinary differential equations issolved by shooting procedure using fourth order Runge-Kutta Method. The effects of permeability, magnetic parameter, Schmidt number, Soret number and Hall parameter over velocity, temperature and concentration profiles, Skin friction, rate of heat and mass transferat the plate are discussed in detail.
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    EFFECT OF MAGNETIC FIELD ON STEADY BOUNDARY LAYER SLIP FLOW ALONG WITH HEAT AND MASS TRANSFER OVER A FLAT POROUS PLATE EMBEDDED IN A POROUS MEDIUM
    (Global Journal of Pure and Applied Mathematics, 2017) Sumathi K; Arunachalam T; Kavitha R
    In this study, we investigate the effect of magnetic field on steady boundary layer flow along with heat and mass transfer over a flat porous plate with slip boundary condition at the boundary in a porous medium using shooting method with fourth order Runge-Kutta Method. The velocity, temperature and concentration distribution are calculated for different governing parameters. The effect of various non-dimensional parameters like magnetic parameter (M), Schmidt number (𝑆𝑐), Soret number (𝑆𝑟), Suction/blowing parameter (𝑆)are investigated with the aid of graphs. The effect of these dimensionless parameters skin-friction, rate of heat and mass transfer are discussed in detail to understand the physical aspects of the solutions
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    PHYTOCHEMICAL PROFILE AND LARVICIDAL ACTIVITY OF AQUEOUS EXTRACT OF OCIMUM AMERICANUM AGAINST MOSQUITO VECTORS
    (SpringerLink, 2023) Mathiyazhagan, Narayanan; Vijay A; Sabariswaran, Kandasamy; Omaima, Nasif; Sulaiman Ali, Alharbi; Ramalingam, Srinivasan; Kavitha R
    The primary goal of this research was to evaluate the phytochemicals, including bioactive components of Ocimum americanum extracts and assess their larvicidal potential against 3rd and 4th instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus. The aqueous extraction process on O. americanum provides higher yield (9.61 ± 0.11%) and a significant volume of phytochemicals (tannins, saponins, terpenoids, flavonoids, alkaloids, protein, and carbohydrate) than other solvents (methanol, ethanol, acetone, petroleum ether, and chloroform) extracts. Fourier-transform infrared spectroscopy and high-performance liquid chromatography analyses revealed about eight predominant phytochemicals/functional groups in O. americanum aqueous extract. Surprisingly, in gas chromatography–mass spectrometry analysis, about 30 bioactive components were found in the aqueous extract of O. americanum, the majority of which had previously been identified as medicinally valuable bioactive components. Furthermore, these bioactive components containing aqueous extract demonstrated significant larvicidal activity against 3rd and 4th instar larvae of A. aegypti, An. stephensi, and C. quinquefasciatus after 24 h of treatment at concentrations ranging from 35 to 50 mg mL−1. Thus, their outstanding larvicidal potential on 3rd and 4th instar larvae, the phytochemicals present in the aqueous extract of O. americanum could be used to control mosquito duplication and vector-borne diseases.