Browsing by Author "Karthika, K"

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    ANTI-OBESITY, ANTI-DIABETIC AND ANTI-INFLAMMATORY ACTIVITY OF CAMPONOTUS COMPRESSUS EXTRACT; IN VITRO AND IN-SILICO STUDIES
    (National Documentation Centre, 2023-12) Karthika, K; Yamuna, R
    Background: In recent years, there has been a growing interest in the potential health benefits of insects, mainly ants, due to the, in them, presence of potential bioactive substances that can play a major role in therapeutic research. In the present study, the therapeutic potential of Camponotus compressus extract was studied, focusing on its bioactive compounds and their diverse applications. Methods: The anti-obesity, anti-diabetic, and anti-inflammatory activity of the C. compressus extract was assessed through various assays, i.e., its anti-obesity potential was determined by the pancreatic lipase inhibition assay, the anti-diabetic activity was analyzed using an α-amylase inhibition assay, whereas the anti-inflammatory activity was studied using a heat induced hemolysis and albumin denaturation inhibition assay. The extract’s mode of action was explored through in-silico studies, whereas ADMET properties were also evaluated. Results: In line with previous findings, the GC-MS analysis revealed 32 bioactive compounds, including some major constituents, such as the 2,3-dihydroxypropyl elaidate and lycoxanthin. The extract exhibited concentration-dependent anti-obesity effects and α-amylase inhibition, suggesting anti-diabetic potential. The anti-inflammatory properties of the extract were confirmed through heat-induced hemolysis and albumin denaturation inhibition assays. The in-silico studies revealed strong binding affinities with target proteins, whereas ADMET analysis supported drug-likeness. Conclusion: Based on our results, the C. compressus extract holds therapeutic promise that could potentially be useful against obesity, diabetes, and inflammation. The study provides insights into its mode of action, supporting its potential as a novel drug candidate.
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    INVESTIGATION ON STRUCTURAL AND MAGNETIC PROPERTIES OF COBALT DOPED MAGNESIUM FERRITE NANOPARTICLES
    (International Journal of ChemTech Research, 2014) Balavijayalakshmi, J; Sudha, T; Karthika, K
    Nanosized spinel ferrites have attracted considerable attention for their interesting structural, magnetic and electrical properties. The physical and chemical properties of nanomaterials have been enhanced because of their surface-to-volume ratio. To search for new good gas-sensing materials and the new properties of conventional materials has become an active research field. Magnesium ferrite is a most versatile ferrite, due to its high resistivity and low eddy currents. Also the technological importance of cobalt ferrite has motivated several studies on the synthesis as well as the physical properties of this material. Hence an attempt is made to synthesize cobalt doped magnesium ferrite nanoparticles (Mg0.6Co0.4Fe2O4) by co-precipitation method. Magnesium chloride (MgCl 2.6H2O), Cobaltous Chloride (CoCl2.6H2O), anhydrous Ferric Chloride (FeCl3) along with sodium hydroxide (NaOH) is used as raw materials. Magnesium-Cobalt ferrite sample annealed at 600 ○ C are subjected to X-ray diffraction to calculate the average nano-crystalline size using Debye - Scherrer formula and is found to be 2-4 nm. The FT-IR spectrum of the sample is recorded and the characteristic absorption bands are observed at 578 cm -1 and 406 cm -1 corresponding to tetrahedral and octahedral sites respectively. The morphological analysis of the sample is studied using Scanning Electron Microscope (SEM). The magnetic properties of the cobalt doped magnesium ferrite nano particles are studied using Vibrating Sample Magnetometer (VSM) and the magnetic properties are found to be improved due to cobalt doping.