Browsing by Author "Kandasamy, Sabariswaran"

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ADVANCED SYNTHESIS, COMPREHENSIVE CHARACTERIZATION, AND POTENT CYTOTOXICITY OF 2,6-BIS(2-AMINOPHENYLIMINO)METHYL)-4-METHOXYPHENOL AND ITS BINUCLEAR COPPER(II) COMPLEX (Article)
(Nature Research, 2025-02-26) Praveen S; Prabakarakrishnan R; Parinamachivayam G; Natarajan A; Venkatesan, Elumalai Perumal; Geetha K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Pugazhendhi, Arivalagan; Kandasamy, Sabariswaran; Hasan, Nasim
The imine base and Cu2+ precursors were combined using magnetic stirring to formulate the Cu2+ complexes. The formation of the imine base was confirmed by electronic and vibrational spectra, proton NMR, LC-mass spectrometry, and computational studies, which also optimized the final structure. The Cu2+ complexes were characterized using electronic and vibrational spectra, magnetic susceptibility, molar conductivity, a variable temperature magnetometer, and ESR spectroscopy. Cyclic voltammetry revealed electron transfer from Cu2+ to Cu+ within the complex. The in vitro tumour activity of the Cu2+ complexes and imine base were evaluated on the A431 cell line using the MTT assay. DFT studies validated the structural stability of the imine base. The antiferromagnetic behaviour observed at low temperatures suggests that these Cu2+ complexes could be useful in heavy magnetic materials. Due to their electron transfer properties, Cu2+ complexes also hold potential for use in electroplating systems and sensors. The complexes exhibited high efficacy on the cell line, aligning with clinical objectives. The Cu2+ complexes are represented as [MLR], where M is the metal, L is the imine base, and R = [C₆H₅COO] or R = [C₆H₄COO(NH₂)].
CARBON-BASED NANOPARTICLES FOR NEURAL REGENERATION (Book Chapter)
(Springer Science and Business Media B.V., 2025-02-21) Maghimaa M; Bharath S; Kandasamy, Sabariswaran
Carbon-based nanoparticles, particularly carbon nanotubes (CNTs), have demonstrated significant potential in neural regeneration due to their exceptional properties. Their high electrical conductivity and mechanical strength mimic the natural characteristics of neural tissues, supporting neuronal growth and function. Additionally, CNTs exhibit high biocompatibilityBiocompatibility, ensuring minimal toxicityToxicity and making them suitable for use in implantable neural interfaces. A key factor in their effectiveness is the ability to functionalize CNTs through chemical modifications. These modifications enhance their interaction with biological systems, improving neuronal attachment and facilitating the delivery of therapeuticTherapeutics agents. This targeted delivery provides essential growth factors and medications directly to damaged areas, promoting more effective nerve regeneration. Research indicates that CNTs contribute significantly to peripheral nerve regenerationRegeneration. They are utilized to create composite scaffolds that support axonal growth and aid in the repair of damaged neural tissues. When integrated into polymeric matrices, CNTs enhance cell adhesion and neurite outgrowth, both of which are crucial for neuronal recovery. Future research is expected to further advance the use of CNTs in neural regeneration. Innovations in functionalization techniques and broader clinical applications hold the potential to make effective treatments for nerve damage and degenerative diseases increasingly attainable. In summary, CNTs represent a powerful and versatile tool in neural regeneration, offering promising solutions for repairing nerve damage.
CHITOSAN-BASED INSECTICIDE FORMULATIONS FOR INSECT PEST CONTROL MANAGEMENT: A REVIEW OF CURRENT TRENDS AND CHALLENGES (Review)
(Elsevier B.V., 2024-11) Mohan, Kannan; Kandasamy, Sabariswaran; Rajarajeswaran, Jayakumar; Sundaram, Thanigaivel; Bjeljac, Marko; Surendran, Ramya Preethi; Ganesan, Abirami Ramu
Future agricultural practices necessitate green alternatives to replace hazardous insecticides while distinguishing between pests and beneficial insects. Chitosan, as a biological macromolecule derived from chitin, is biodegradable and exhibits low toxicity to non-target organisms, making it a sustainable alternative to synthetic pesticides. This review identifies chitosan-derivatives for insecticidal activity and highlights its efficacy including genotoxicity, defense mechanism, and disruption of insect's exoskeleton at different concentrations against several insect pests. Similarly, synergistic effects of chitosan in combination with natural extracts, essential oils, and plant-derived compounds, enhances insecticidal action against various pests was evaluated. The chitosan-based insecticide formulations (CHIF) in the form of emulsions, microcapsules, and nanoparticles showed efficient insecticide action on the targeted pests with less environmental impact. The current challenges associated with the field-trial application were also recognized, by optimizing potent CHIF-formulation parameters, scaling-up process, and regulatory hurdles addressed alongside potential solutions. These findings will provide insight into achieving the EU mission of reducing chemical pesticides by 50 %.
A COMPREHENSIVE REVIEW ON TAILORING FACTORS OF POROUS BISMUTH OXYHALIDE PHOTOCATALYSTS FOR WASTEWATER TREATMENT APPLICATION (Article PDF)
(Taiwan Institute of Chemical Engineers, 2025-01) Kar, Prasenjit; Sathiyan, Govindasamy; Vivekanandan, K E; Venkatesan, Geetha; Siva, Govindasamy; Subramani, Ramesh; Kandasamy, Sabariswaran
Background: Photocatalysis is a green, environmentally friendly approach for converting organic contaminants into harmless byproducts. Especially, Bismuth oxyhalides (BiOX, where X = Cl, Br and I) have emerged as promising photocatalysts for wastewater treatment due to their layered-by-layered structure, strong chemical stability and nontoxicity in compare to other metal oxides, which makes the photocatalyst advantageous for photocatalytic application. Methods: This review provides an overview of recent developments in the synthesis and application of BiOXbased porous photocatalysts for the removal of organic contaminants from wastewater. Firstly, morphologycontrolled synthesis of BiOX in degradation of organic contaminants. Then, modulation of electronic structure through doping, facet engineering and surface engineering has been highlighted for better photocatalytic applications. Furthermore, fabrication of diverse heterojunctions and co-catalyst loading upon BiOX are introduced, which can vary photocatalytic activity towards the degradation of organic contaminants. Significant findings: Finally, this review ended on the future trend and prospects of BiOX for the creation of potential high-performance photocatalysts in the near future. The porous structure of BiOX improved photocatalytic activity, pollutant degradation efficiency, visible light response charge carrier separation, and stability. Overall, bismuth oxyhalide photocatalysts have a lot of potential for effective and long-term wastewater treatment, and their development represents an important step towards addressing the global water pollution crisis.
DECIPHERING THE IMPORTANCE OF NANOENCAPSULATION TO IMPROVE THE AVAILABILITY OF BIOACTIVE MOLECULES IN FOOD SOURCES TO THE HUMAN BODY (Article)
(Elsevier Ltd, 2025-02) Pugazhendhi, Arivalagan; Alshehri, Mohammed Ali Mohammed Ali; Kandasamy, Sabariswaran; Sarangi, Prakash Kumar; Sharma, Ashutosh
Various bodily functions are maintained, and health benefits are provided by food-derived bioactive components. Fruits and vegetables contain numerous beneficial components, including vitamins, minerals, antioxidants, enzymes, and phytonutrients. However, the body's ability to absorb these substances at a given rate and degree frequently limits their bioavailability. If food-derived bio actives are used as therapeutic or dietary interventions, this limitation can result in low efficacy and suboptimal results. Recently, nanotechnology has been a useful method for increasing the bioavailability of bioactive compounds produced from food. Active ingredients can be delivered and absorbed more efficiently with the help of nanotechnology. By altering their size or surface properties, bioactive components can be made more soluble, permeable, and bioavailable through nanotechnology. The present review will provide an overview of the various bioactive components, the application of nanotechnology to improve the availability of bioactive molecules to humans and animals, and the challenges and safety concerns associated with nanotechnology in the production of food-derived bioactive molecules.
EXPERIMENTAL AND IN SILICO APPROACHES TO IDENTIFY A SUSTAINABLE SOURCE OF BIOPLASTICS FROM SEAWEEDS (Article)
(Springer Science and Business Media Deutschland GmbH, 2025-03-21) Sarangam, Babu; Prabhu, Dhamodharan; Raja, Rathinam; Sangeetha, Pugalendran; Jayappriyan K.R; Kandasamy, Sabariswaran; Narayanan, Mathiyazhagan
Carrageenan was extracted from Kappaphycus alvarezii, alginate from Sargassum wightii, and agar from Gracilaria crassa and Gelidiella acerosa respectively. The plastic film formed with carrageenan, sodium alginate, and corn starch (F6) showed a higher tensile strength (TS) of 3.051 N/mm2 followed by a TS value of 3.073 N/mm2 for films made of carrageenan, sodium alginate, and agar (F7). The lowest tensile strength (0.984 N/mm2) was observed in agar film (F3). Garden soil led to higher biodegradation of the seaweed films compared to clay and beach soil. The films F6 and F7 biodegraded with a loss of 90 and 74% respectively within 30 days in garden soil. Given the better biodegradability and better TS and E value, the film F6 (carrageenan sodium alginate and corn starch) can be improvised for wider applications in food packaging and biomedical applications. FT-IR results of F6 bioplastics possessed characteristic peaks that support the chemical properties of bioplastics derived from seaweeds. The molecular docking and molecular dynamics simulation analysis showed that these three biopolymers maintained favorable binding and strong interaction with the cutinase (CutL1) enzyme which is widely reported for the biodegradable function in Aspergillus oryzae. SEM images of the F6 bioplastic show a heterogeneous structure with enhanced roughness.
HAEMATOCOCCUS: BIOCHEMISTRY, BIOTECHNOLOGY AND BIOMEDICAL APPLICATIONS
(Springer Nature, 2023-01-01) Raja, Rathinam; Hemaiswarya, Shanmugam; Narayanan, Mathiyazhagan; Kandasamy, Sabariswaran
This book offers a comprehensive analysis of microalgal cultivation methods and optimization of astaxanthin production for various applications, including clinical uses, algae polymers, proteins and pigments, food applications and packaging, algae forming, cosmetics, and more. Microalgae are unicellular living forms and are the primary producers that play a major role in the ecosystem. Commercially, while many documents are available, some recent fields are yet to be explored. The book comprises 19 chapters contributed by experts and reviews the recent developments in the cultivation, harvest, and genetic engineering of H. pluvialis-derived astaxanthin. It also discusses their bottlenecks and challenges in commercial-scale production, as well as current and prospective global market. Current research supports the exploration of new topics and practical applications of microalgae and their products, which will also benefit academia. The book will be an importantresource for researchers and industry, providing comprehensive knowledge on broad topics. Flow charts, updated methods, and colour images are included to help the readers' understanding.
HAEMATOCOCCUS: BIOCHEMISTRY, BIOTECHNOLOGY AND BIOMEDICAL APPLICATIONS (Book)
(Springer Nature, 2023-01-01) Raja, Rathinam; Hemaiswarya, Shanmugam; Narayanan, Mathiyazhagan; Kandasamy, Sabariswaran; Jayappriyan, K R
This book offers a comprehensive analysis of microalgal cultivation methods and optimization of astaxanthin production for various applications, including clinical uses, algae polymers, proteins and pigments, food applications and packaging, algae forming, cosmetics, and more. Microalgae are unicellular living forms and are the primary producers that play a major role in the ecosystem. Commercially, while many documents are available, some recent fields are yet to be explored. The book comprises 19 chapters contributed by experts and reviews the recent developments in the cultivation, harvest, and genetic engineering of H. pluvialis-derived astaxanthin. It also discusses their bottlenecks and challenges in commercial-scale production, as well as current and prospective global market. Current research supports the exploration of new topics and practical applications of microalgae and their products, which will also benefit academia. The book will be an importantresource for researchers and industry, providing comprehensive knowledge on broad topics. Flow charts, updated methods, and colour images are included to help the readers' understanding.
NON-INVASIVE MEASUREMENT OF SPOILAGE OF PACKED FISH USING HALOCHROMIC SENSOR (Article)
(Emerald Publishing, 2025-02-21) Devarayan, Kesavan; Palanisamy, Yazhiniyan; Mohan, Gangeswar; Theivasigamani, Anand; Kandasamy, Sabariswaran; Sekar, Vimaladevi; Siluvai John, Evon Umesh; Sukumaran, Monikandon; Marimuthu, Ramar; Anjappan, Hema
Purpose: This study aims to develop a pH-functional thin-film sensor for non-invasive measurement of spoilage of packed fish. Design/methodology/approach: At first, polymers of natural origin such as hydroxy(propyl)methyl cellulose, potato dextrose agar and starch alongside a pH sensitive-mixed indicator formulation were used to produce thin film sensor. The developed thin film sensor was tested for monitoring the spoilage of seafood stored at 4°C. Using ultraviolet-visible and Fourier-transform infrared spectroscopy, the halochromic sensor was characterised. In addition, the halochromic response of the thin film was directly correlated to the total volatile base nitrogen emitted by the packaged fish, pH, microbial activity and sensory evaluation. Findings: The results suggested the developed biopolymer-based thin film sensor showed different colours in line with the spoilage of the packed fish, which could be well correlated with the total volatile base nitrogen, microbial activity and sensory evaluation. In addition, the thin film sensors exhibited a high degree of biodegradability. The biopolymers-based thin film halochromic sensor has exhibited excellent biodegradability along with sensitiveness towards the spoilage of the packed fish. Originality/value: In the future, consumers and retailers may prefer seafood containers equipped with such halochromic sensors to determine the degree of food deterioration as a direct indicator of food quality.
PREFACE (Book Chapter)
(Springer Nature, 2023-01-01) Raja, Rathinam; Hemaiswarya, Shanmugam; Narayanan, Mathiyazhagan; Kandasamy, Sabariswaran; Jayappriyan K.R.
THEORETICAL INSIGHTS AND ANTICANCER POTENTIAL OF 2,6-BIS((E)-(2-AMINO-4-NITROPHENYLIMINO)METHYL)-4-METHOXYPHENOL AND ITS BINUCLEAR CU(II) COMPLEX (Article)
(John Wiley and Sons Ltd, 2025-02) Praveen S; Parinamachivayam G; Jeyaraman P; Prabakarakrishnan R; Natarajan A; Geetha K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Pugazhendhi, Arivalagan; Kandasamy, Sabariswaran
This study explores the synthesis and applications of a new Schiff base, 2,6-bis((E)-(2-amino-4-nitrophenylimino)methyl)-4-methoxyphenol (HL), and its copper(II) complexes. The Schiff base was prepared by reacting 2-amino-4-nitroaniline with 2,6-diformyl-4-methoxyphenol and characterized using techniques like microanalysis, UV–Vis, IR spectroscopy, 1H-NMR, and LC–MS, confirming its structure. Theoretical studies provided insights into its molecular geometry and electronic properties. Cyclic voltammetry of the copper complex revealed diffusion-controlled electrochemical behavior, involving a single-electron transfer. Both the Schiff base and its Cu(II) complexes exhibited promising anticorrosion and anticancer activities, highlighting their multifunctional potential in industrial and biomedical applications. This study emphasizes the importance of comprehensive characterization in developing innovative materials with practical uses.