Browsing by Author "Geetha, Venkatesan"

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THE COMPREHENSIVE REVIEW ON 3D PRINTING- PHARMACEUTICAL DRUG DELIVERY AND PERSONALIZED FOOD AND NUTRITION
(Elsevier Ltd, 2024-11) Meenakshi, Murugan; Selva Kumar, Ramasamy; Geetha, Venkatesan; Jintae, Lee; Selvaraj, Barathi; Sabariswaran, Kandasamy; Prakash Kumar Sarangi
Three-dimensional printing is one of the emerging technologies that is gaining interest from the pharmaceutical industry as it provides an opportunity to customize drugs according to each patient's needs. Combining different active pharmaceutical ingredients, using different geometries, and providing sustained release enhances the effectiveness of medicine. One of the most innovative uses of 3D printing is producing fabrics, medical devices, medical implants, orthoses, and prostheses. This review summarizes the various 3D printing techniques such as stereolithography, inkjet printing, thermal inkjet printing, fused deposition modelling, extrusion printing, semi-solid extrusion printing, selective laser sintering, and hot-melt extrusion. Also, discusses the drug relies profile and its mechanisms, characteristics, and applications of the most common types of 3D printed API formulations and its recent development. Here, Authors also, summarizes the central flow of 3D food printing process and knowledge extension toward personalized nutrition.
THE COMPREHENSIVE REVIEW ON 3D PRINTING- PHARMACEUTICAL DRUG DELIVERY AND PERSONALIZED FOOD AND NUTRITION
(Elsevier Ltd, 2024) Meenakshi, Murugan; Selva Kumar, Ramasamy; Geetha, Venkatesan; Jintae, Lee; Selvaraj, Barathi; Sabariswaran, Kandasamy; Prakash Kumar, Sarangi
Three-dimensional printing is one of the emerging technologies that is gaining interest from the pharmaceutical industry as it provides an opportunity to customize drugs according to each patient's needs. Combining different active pharmaceutical ingredients, using different geometries, and providing sustained release enhances the effectiveness of medicine. One of the most innovative uses of 3D printing is producing fabrics, medical devices, medical implants, orthoses, and prostheses. This review summarizes the various 3D printing techniques such as stereolithography, inkjet printing, thermal inkjet printing, fused deposition modelling, extrusion printing, semi-solid extrusion printing, selective laser sintering, and hot-melt extrusion. Also, discusses the drug relies profile and its mechanisms, characteristics, and applications of the most common types of 3D printed API formulations and its recent development. Here, Authors also, summarizes the central flow of 3D food printing process and knowledge extension toward personalized nutrition.
DESIGN AND SYNTHESIS OF SIMPLE QUINOLINE-BASED ORGANIC MOLECULES AS DUAL/MULTIFUNCTIONAL CHEMOSENSORS FOR THE DETECTION OF CU2+/FE3+ IONS
(Elsevier B.V, 2024) Pitchai, Marimuthu; Ramu, Andy; Venkatesh, Nachimuthu; Asrar Ahamed, A; Geetha, Venkatesan; Arunachalam, Chinnathambi; Sabariswaran, Kandasamy
The current research deals with the sensitivity of a turn-on-off fluorescence chemosensor using the probe, namely (E)-2-(((2‑hydroxy-5-methylphenyl) imino)methyl) quinolin-8-ol (HQ-AMP) as a selective detection of Cu2+/Fe3+ ions in DMSO: H2O (1:1, v/v). The probe HQ-AMP was synthesized using a simple acid catalyst, Schiff base condensation, which involves the reaction between aldehyde and amine. This probe shows a significant fluorescence response towards Cu2+ and Fe3+ ions among the other alkaline earth metal ions. The HQ-AMP forms a 1:1 stoichiometry complex with a high binding constant for Cu2+ and Fe3+ ions with a low detection limit of 34 nM and 47 nM, respectively. Due to their strong intermolecular charge transfer properties, the probe HQ-AMP shows intense fluorescence at 488 nm upon excitation at 350 nm. The selective fluorescence quenching of probe HQ-AMP with Cu2+/Fe3+ ions shows static/dynamic quenching and their quenching constant of 1.93 × 10−8 and 2.06 × 10−8, respectively. Also, the probe shows the highest selectivity towards Cu2+/Fe3+ ions over the other tested metal ions.
ENHANCING SUSTAINABILITY: CHITOSAN BIOPOLYMERS WITH AG NANOPARTICLES FOR ECO-FRIENDLY APPLICATIONS IN FOOD PACKAGING
(Springer Link, 2024-01-23) Sharmila, Chandran; Arthi, Pricillia; Arunadevi, Natarajan; Geetha, Venkatesan
Converting organic solid waste into biomaterials has recently contributed to reducing economic reliance on fossil fuels. Polymers derived from biomass are gaining appeal for their biofuel, biomedical, and biocomposite uses. Animal cellulose-based biopolymers such as chitosan, have piqued the interest of researchers seeking access to a sustainable biopolymer material. Chitosan films were developed through the crosslinking of chitosan and citric acid using distilled water as a solvent. A hydrogel thus formed was then cast to produce a free-standing film. A comparative analysis of these films was carried out by integrating silver (Ag) nanoparticles as dopants. The study encompasses the entire process including film synthesis, as well as the evaluation of their morphological and thermal properties. Various techniques were employed for the characterization of the films, which includes UV-Vis spectroscopy, X-ray diffraction, SEM, EDAX, AFM, TGA, and DSC. The results shed light on how the inclusion of Ag nanoparticles influences the characteristics of chitosan. Chitosan films were evaluated for migration potential towards dry foods, yielding satisfactory results in terms of their suitability for food packaging materials. The suspension of chitosan films in water was accompanied by a determination of their physical and chemical properties, revealing that water quality remained at satisfactory levels. These films were identified to meet stringent food grade standards and were observed to contribute to the reduction of biomass through their integration into the natural recycling process.
EXPLORING CUTTING-EDGE ADVANCES IN GREEN AMMONIA PRODUCTION AND STORAGE TECHNOLOGIES
(Elsevier, 2024) Prakash Kumar, Sarangi; Rajesh K, Srivastava; Gitanjali, J; Govindasamy, Sathiyan; Geetha, Venkatesan; Sabariswaran, Kandasamy
Green ammonia’s exceptional qualities, such as its high energy density, ease of handling, and robust transportation and storage infrastructure, position it as a leading choice for long-term energy storage and carbon-free fuel applications. This review comprehensively explores material-based methods for producing, storing, and utilizing green ammonia, emphasizing key findings with specific quantitative data on energy density, costs, and efficiencies. The critical need for efficient and sustainable ammonia production is emphasized due to its central role in reducing greenhouse gas emissions and facilitating the transition to a low-carbon economy. Various material-based approaches and catalysts, including innovative reactor designs and electrochemical processes, are meticulously examined. Furthermore, the review delves into safe and efficient storage methods for green ammonia, particularly exploring the potential of solid-state materials to regulate ammonia adsorption and release. Addressing challenges such as safety concerns and system integration is crucial for realizing the full potential of green ammonia storage solutions. Moreover, the economic benefits of green ammonia in chemical manufacturing, fertilizer production, and power generation underscore its multifaceted advantages across industries. Ultimately, this analysis highlights green ammonia’s role as a versatile and sustainable energy carrier, essential for driving towards a greener future.
MODIFICATION OF CELLULOSE ACETATE MEMBRANE BY INTEGRATING MAGNETITE@XANTHAN GUM NANOCOMPOSITE TO ENHANCE PERFORMANCE CHARACTERISTICS
(Elsevier, 2024) Sathish, Raam Ravichandran; Chitra Devi, Venkatachalam; Mothil, Sengottian; Deenadhayalan, Ramachandran; Asswin, Saminathan; Ananth, Raja; Geetha, Venkatesan; Arunachalam, Chinnathambi; Sabariswaran, Kandasamy
Membrane technology, a versatile alternative to traditional separation processes in industries and wastewater treatment, was employed in this study. Membranes were fabricated using cellulose acetate (C), dimethyl sulfoxide (D), and glycerol (G) at various weight percentages. To enhance membrane performance, a Magnetite@Xanthan gum nanocomposite (NC) was synthesized in-situ and analysed using FESEM-EDS. Experimental investigations incorporated the doping of the membrane with NC at different percentages (0 wt%, 0.1 wt%, 0.5 wt%, and 1.0 wt%). Increasing NC content resulted in smoother surfaces, improving anti-fouling characteristics, as confirmed by AFM. Integrating NC into the pure membrane reduced the contact angle, with 1.0 wt% Fe3O4@XG recording the lowest angle at 56.18°. Physical property analyses covered viscosity, pH, water uptake percentage, and porosity to assess the impact of NC integration. Under 5 atm pressure, the 1.0 wt% Fe3O4@XG membrane exhibited a substantial pure water flux of 3069.55 lit.m-2 h−1 compared to pure CDG. Furthermore, the 0.5 wt% Fe3O4@XG membrane displayed the highest flux recovery ratio (60.42%) compared to pure CDG (48.18%). A biodegradability test showed that the 1.0 wt% Fe3O4@XG membrane exhibited superior weight loss (43.75%) over 28 days. This research underscores the potential of these membranes for diverse applications, including wastewater treatment and sustainability.