Browsing by Author "Chinnathambi, Arunachalam"

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    ADVANCED SYNTHESIS, COMPREHENSIVE CHARACTERIZATION, AND POTENT CYTOTOXICITY OF 2,6-BIS(2-AMINOPHENYLIMINO)METHYL)-4-METHOXYPHENOL AND ITS BINUCLEAR COPPER(II) COMPLEX (Article)
    (Nature Research, 2025-02-26) Praveen S; Prabakarakrishnan R; Parinamachivayam G; Natarajan A; Venkatesan, Elumalai Perumal; Geetha K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Pugazhendhi, Arivalagan; Kandasamy, Sabariswaran; Hasan, Nasim
    The imine base and Cu2+ precursors were combined using magnetic stirring to formulate the Cu2+ complexes. The formation of the imine base was confirmed by electronic and vibrational spectra, proton NMR, LC-mass spectrometry, and computational studies, which also optimized the final structure. The Cu2+ complexes were characterized using electronic and vibrational spectra, magnetic susceptibility, molar conductivity, a variable temperature magnetometer, and ESR spectroscopy. Cyclic voltammetry revealed electron transfer from Cu2+ to Cu+ within the complex. The in vitro tumour activity of the Cu2+ complexes and imine base were evaluated on the A431 cell line using the MTT assay. DFT studies validated the structural stability of the imine base. The antiferromagnetic behaviour observed at low temperatures suggests that these Cu2+ complexes could be useful in heavy magnetic materials. Due to their electron transfer properties, Cu2+ complexes also hold potential for use in electroplating systems and sensors. The complexes exhibited high efficacy on the cell line, aligning with clinical objectives. The Cu2+ complexes are represented as [MLR], where M is the metal, L is the imine base, and R = [C₆H₅COO] or R = [C₆H₄COO(NH₂)].
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    THEORETICAL INSIGHTS AND ANTICANCER POTENTIAL OF 2,6-BIS((E)-(2-AMINO-4-NITROPHENYLIMINO)METHYL)-4-METHOXYPHENOL AND ITS BINUCLEAR CU(II) COMPLEX (Article)
    (John Wiley and Sons Ltd, 2025-02) Praveen S; Parinamachivayam G; Jeyaraman P; Prabakarakrishnan R; Natarajan A; Geetha K; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Pugazhendhi, Arivalagan; Kandasamy, Sabariswaran
    This study explores the synthesis and applications of a new Schiff base, 2,6-bis((E)-(2-amino-4-nitrophenylimino)methyl)-4-methoxyphenol (HL), and its copper(II) complexes. The Schiff base was prepared by reacting 2-amino-4-nitroaniline with 2,6-diformyl-4-methoxyphenol and characterized using techniques like microanalysis, UV–Vis, IR spectroscopy, 1H-NMR, and LC–MS, confirming its structure. Theoretical studies provided insights into its molecular geometry and electronic properties. Cyclic voltammetry of the copper complex revealed diffusion-controlled electrochemical behavior, involving a single-electron transfer. Both the Schiff base and its Cu(II) complexes exhibited promising anticorrosion and anticancer activities, highlighting their multifunctional potential in industrial and biomedical applications. This study emphasizes the importance of comprehensive characterization in developing innovative materials with practical uses.